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Effect of different treatments on dentin hypersensitivity: evaluation of cytotoxicity and randomized clinical study

Grant number: 20/07443-9
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2022
Effective date (End): April 30, 2023
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Principal researcher:Ticiane Cestari Fagundes
Grantee:Fernanda de Souza e Silva Ramos
Home Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


The aim of this study will be to investigate the effects of different categories of treatments for dentin hypersensitivity in relation to cytotoxicity and through a randomized clinical study, using the following protocols: Placebo Varnish (negative control - PV), Fluoride Varnishes (Duraphat, positive control - FV); experimental varnish (NaF 5% + 5% TMP - TV); bioactive ceramic crystalline solution (Biosilicato® - SS); Amelotin Solution (AS); dental adhesive system (Single Bond Universal - SB); light-cured fluoride varnish (PRG - LV). The cytotoxicity analysis will be performed using protein quantification by the BCA method and the Alamar Blue solution. Of the six treatments proposed in vitro, the four that obtained the best results will be tested in vivo: SS, AS, SB and LV, in addition to the FV group. Two hundred and forty teeth (48 for each treatment) with exposed root with dentin hypersensitivity not cavitated or beginning to cavitate (up to 1mm deep, without the need for restoration) will be treated in a randomized and parallel study. Each patient will be treated with the same desensitizing protocol. The degree of dentin sensitivity will be analyzed using the Visual Analogue Scale (VAS), and Computerized Visual Scale (CoVAS), at baseline (prior to treatment), and at 7, 15, 30 days, 6 and 12 months after treatment. The results will be subjected to specific statistical tests. It is expected that the present study will contribute to the knowledge about the mechanism involved in new desensitizing treatment, as well as to obtain an innovative and effective clinical protocol for dentin hypersensitivity. (AU)

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