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Mitochondrial dynamics in the control of metabolism and function of tissue macrophages

Grant number: 20/15941-9
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): March 01, 2022
Effective date (End): February 28, 2026
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal researcher:Pedro Manoel Mendes de Moraes Vieira
Grantee:João Victor Virgilio da Silva
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Immune cells play a central role in maintaining the whole-body homeostasis. Immune cells are constantly adapting their metabolism and function upon systemic alterations. Immunometabolism has helped to understand how these cells are important in physiological and pathological conditions. Macrophages have different activation profiles and metabolic adaptations in different contexts and microenvironments. Despite great advances in the field of immunometabolism, most studies are performed with macrophages derived from mice bone marrow or from human circulating monocytes. There is a constant need to understand the metabolic responses of tissue resident macrophages. Mitochondria are central players in the control of cellular metabolism, being important in the production of ATP, control of the redox state, among other functions. Mitochondria are dynamic organelles, assuming elongated or fragmented forms, according to the cellular context. Mitochondrial architecture is directly related to their specific functions. Mitochondrial morphology appears to play a role in immune responses against pathogens and Obesity-induced adipose tissue inflammation. Thus, our goal is to understand how the mitochondrial dynamics machinery controls the macrophage metabolismin non-infectious inflammatory microenvironment, such as obesity-induced adipose tissue inflammation and the subsequent insulin resistance. Thus, we will be able to understand how mitochondrial dynamics controls macrophages function in the inflammatory context of Obesity. (AU)

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