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Design and production of bone vascular scaffolds

Grant number: 21/11803-3
Support type:Scholarships abroad - Research Internship - Doctorate (Direct)
Effective date (Start): October 01, 2022
Effective date (End): September 30, 2023
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal researcher:Antonio Claudio Tedesco
Grantee:Henrique Luis Piva
Supervisor abroad: Ibrahim Tarik Ozbolat
Home Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Research place: Pennsylvania State University, United States  
Associated to the scholarship:20/04009-6 - Development of a novel bioink for 3D printing scaffolds for regeneration of cartilage tissues, BP.DD

Abstract

Research on novel compatible biomaterials for three-dimensional (3D) bioprinting exhibiting fast crosslinking properties and multiple advanced functions (like good cell viability, transparency, exhibiting good cell fusion potential) used as scaffolds is essential for advances in customized applications in many research fields, including tissue engineering. Many studies have explored such biomaterials to improve its functionality, however, there is a lack of vascularization process in scaffolds for implants, this is an essential factor for successful implants of bioengineered tissues, and a tissue with few millimeters in volume cannot survive by diffusion for oxygen and nutrients, requiring then a formation of capillaries to supply it. This proposal of study will use the combination of Gellan-Gum, and Alginate as bioinks in a gelatin-based hydrogel to produce vascularized scaffolds with human umbilical vein endothelial cells (HUVECs), combined with a PVP and gelatin-based hydrogel containing human fetal osteoblasts for future bone regeneration processes, avoiding the lack of vascularization. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
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