In vitro photoprotective and ex vivo antilipoperoxidative efficacy of rosmarinic acid associated with UVB filters

• Grant number: 21/13276-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: April 01, 2022
• End date: March 31, 2023
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: André Rolim Baby
• Grantee: Pedro Ivo de Souza Macedo
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The knowledge of the harmful effects that exposure to ultraviolet (UV) radiation promotes on the skin has led to the population's awareness of the routine use of sunscreens, as well as the advancement of scientific research to improve the efficacy and safety of these formulations. Sunscreens can reflect and/or absorb UV radiation, however, they do not demonstrate relevant effectiveness against free radicals, which, in the skin, are responsible for oxidative damage to DNA, premature aging, and skin cancer. Natural products have antioxidant activity, so rosmarinic acid was selected, an ester of caffeic acid, with proven benefits for the skin tissue. Three samples will be prepared with UVB filters: ethylhexyl methoxycinate, octocrilene and Ethylhexyl salicylate associated with rosmarinic acid. The samples will be evaluated by in vitro assay of photoprotective efficacy and ex vivo of the antilipoperoxidative property. The results will present perspectives of practical application in the research area of photoprotective and antioxidant cosmetic products, adding a new non-invasive method, to be used for the complementary analysis of photoprotective efficacy.(AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MACEDO, PEDRO IVO DE SOUZA; PINTO, CLAUDINEIA APARECIDA SALES DE OLIVEIRA; HIRAISHI, CAMILA FAUSTINO; MARQUES, GABRIELA DE ARGOLLO; ESCUDEIRO, CASSIANO CARLOS; PESSOA, FABIANA VIEIRA LIMA SOLINO; GREGORIO, JOAO; ROSADO, CATARINA; VELASCO, MARIA VALERIA ROBLES; BABY, ANDRE ROLIM. Enhancing Photoprotection and Mitigating Ex Vivo Stratum Corneum Oxidative Stress: A Multifunctional Strategy Combining Rosmarinic Acid with UVB Filters. ANTIOXIDANTS, v. 14, n. 3, p. 14-pg., 2025-02-26. (24/01920-0, 21/13276-0)

MARQUES, GABRIELA DE ARGOLLO; HIRAISHI, CAMILA FAUSTINO; MACEDO, PEDRO IVO DE SOUZA; PINTO, CLAUDINEIA APARECIDA SALES DE OLIVEIRA; GREGORIO, JOAO; ROSADO, CATARINA; VELASCO, MARIA VALERIA ROBLES; BABY, ANDRE ROLIM. HPLC-TBARS-EVSC (high-performance liquid chromatography-thiobarbituric acid reactive substances-ex vivo stratum corneum) protocol: Selection of the subjects and approach to present the results. International Journal of Cosmetic Science, v. 45, n. 5, p. 8-pg., 2023-10-01. (19/16169-0, 21/13276-0)