Discovery of natural products isolated from fungal lineages as lead candidates for Malaria

• Grant number: 22/01066-4
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: March 01, 2022
• End date: October 31, 2022
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Rafael Victorio Carvalho Guido
• Grantee: Natália Menezes Moreira Borges
• Host Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Associated research grant: 19/17721-9 - The role of Chemistry in holobiont adaptation, AP.TEM

Abstract

Malaria is a lethal parasitic disease with worldwide prevalence and despite investments in the search for new drugs, a high mortality rate is observed. The great structural diversity of natural products as well as their potent biological activities makes them attractive molecules for the discovery and development of new drugs. Among the microorganisms, fungi of different origins have been widely explored as producers of substances with antimalarial activity. On the basis of the importance of the discovery of new antiplasmodial compounds, this project aims to identify and characterize new bioactive compounds isolated from fungal metabolites as lead candidates for the discovery of new antimalarials. The compounds will be prospected from fungal strains and their antiplasmodial and cytotoxic activities will be assessed in standardized in vitro and in vivo assays. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MOREIRA, NATAILIA M.; DE MIRANDA, INGRID T.; DOS SANTOS, JHONATHAN R. N.; OPATZ, TILL; OLIVA, GLAUCIUS; GUIDO, RAFAEL V. C.; CORREA, ARLENE G.. Copper-Catalyzed Synthesis of Pyrrolo[1,2-c]quinazolines and Pyrrolo[2,1-a]isoquinolines and Antiplasmodial Evaluation. Journal of Organic Chemistry, v. 88, n. 13, p. 10-pg., 2023-06-05. (16/20609-8, 13/07600-3, 14/50249-8, 17/19940-4, 20/12904-5, 20/10349-4, 22/01066-4)