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Discovery of natural products isolated from fungal lineages as lead candidates for Malaria

Grant number: 22/01066-4
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): March 01, 2022
Effective date (End): October 31, 2022
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Rafael Victorio Carvalho Guido
Grantee:Natália Menezes Moreira Borges
Home Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Associated research grant:19/17721-9 - The role of Chemistry in holobiont adaptation, AP.TEM

Abstract

Malaria is a lethal parasitic disease with worldwide prevalence and despite investments in the search for new drugs, a high mortality rate is observed. The great structural diversity of natural products as well as their potent biological activities makes them attractive molecules for the discovery and development of new drugs. Among the microorganisms, fungi of different origins have been widely explored as producers of substances with antimalarial activity. On the basis of the importance of the discovery of new antiplasmodial compounds, this project aims to identify and characterize new bioactive compounds isolated from fungal metabolites as lead candidates for the discovery of new antimalarials. The compounds will be prospected from fungal strains and their antiplasmodial and cytotoxic activities will be assessed in standardized in vitro and in vivo assays. (AU)

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