Validation of potential genomic alterations found during the malignant transformation of the pleomorphic adenoma

• Grant number: 21/12567-1
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: July 01, 2022
• End date: December 31, 2022
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Fernanda Viviane Mariano Brum Corrêa
• Grantee: João Figueira Scarini
• Supervisor: Rogerio Moraes Castilho
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Institution abroad: University of Michigan, United States
• Associated to the scholarship: 19/09419-0 - Genomic alterations in the malignant transformation of the Pleomorphic Adenoma, BP.DR

Abstract

Among the tumors that can affect the salivary glands, two entities constitute interesting models for the study of the mechanism of malignant transformation. The first one, the most common benign tumor in the salivary gland, pleomorphic adenoma (PA), may undergo genetic transformations resulting in its malignant counterpart, carcinoma ex-pleomorphic adenoma (CXPA). The latter is a rare and aggressive neoplasm, with metastasis and death in a large percentage of the cases. Both tumors show important findings from the genetic point of view in which many of the alterations found are focal and at specific gene sites. However, there are still many open questions about diagnostic markers, pathogenesis, and target therapy of PA and CXPA. In the present project, we will validate a group of genetic alterations found in PA and CXPA through Whole Exome Sequencing (WES). The validation of the main polymorphisms and mutations found after raw data analysis will be performed by immunohistochemistry. This way, analyzing genetic alterations related to tumorigenesis of PA and tumor progression of CXPA, we intend to add significant knowledge to what is currently known about these tumors, and also to provide information about diagnostic markers, pathogenesis, and tumor target therapy, which reflect in application instruments clinical and benefit of future patients affected by these neoplasias. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SCARINI, JOAO FIGUEIRA; DE LIMA-SOUZA, REYDSON ALCIDES; LAVAREZE, LUCCAS; EMERICK, CAROLINA; MIYAOK, RAFAELLA DINI; SCHIAVON KINASZ, LETICIA RAYSA; MAUNSELL, REBECCA; ABU EGAL, ERIKA SAID; ALTEMANI, ALBINA; MARIANO, FERNANDA VIVIANE. Oral Teratoma with Hairy Polyp-Like Features: A Brief Report of a Rare Presentation. INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, v. N/A, p. 4-pg., 2022-11-03. (21/12567-1, 15/07304-0, 19/09419-0, 19/06809-2)

SCARINI, JOAO FIGUEIRA; LAVAREZE, LUCCAS; DE LIMA-SOUZA, REYDSON ALCIDES; EMERICK, CAROLINA; GONCALVES, MAYARA TREVIZOL; FIGUEIREDO-MACIEL, TAYNA; VIEIRA, GUSTAVO DE SOUZA; KIMURA, TALITA DE CARVALHO; DE SA, RAISA SALES; AQUINO, IARA GONCALVES; et al. Head and neck squamous cell carcinoma: Exploring frontiers of combinatorial approaches with tyrosine kinase inhibitors and immune checkpoint therapy. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, v. 180, p. 14-pg., 2022-12-01. (15/07304-0, 21/12567-1, 19/09419-0, 19/06809-2)