Psychiatric and cognitive manifestations associated with SARS-CoV-2 virus infection

• Grant number: 21/14379-8
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Effective date (Start): June 01, 2022
• Effective date (End): May 31, 2023
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal Investigator: Eurípedes Constantino Miguel Filho
• Grantee: Rodolfo Furlan Damiano
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Preliminary studies with patients infected with the virus SARS-CoV-2 (Severe Acute Respiratory Syndrome-Coronavirus-2) indicate involvement of different organs and systems, including the Central Nervous System (CNS). Changes in the CNS include acute and chronic manifestations involving clinical expressions of a psychiatric nature (eg. anxiety, depression, post-traumatic stress disorder, psychotic disorder), neurological (eg. encephalopathies, headaches, stroke, anosmia and ageusia) or neuropsychiatric (delirium, cognitive changes). The present proposal aims to longitudinally evaluate the psychiatric and cognitive manifestations of SARS-CoV-2 infection in a cohort study. Systemic, psychiatric, neurological and neuropsychological changes will be evaluated in a sample of about 800 patients 6 to 9 months after infection and hospitalization by COVID-19. Pathophysiological mechanisms will be investigated from the correlation of these findings with the research of a panel of cytokines in the blood, in addition to general laboratory tests, both at baseline and after 6 months of infection, in addition to a broad clinical evaluation that can identify predictive factors for long-term psychiatric and cognitive outcomes. The findings of this study will allow for greater knowledge about the manifestations of COVID-19 in the CNS, its correlations with clinical and biological findings in the chronic phase, as well as their presence in the acute phase, can predict the expression of neuropsychiatric manifestations in the chronic phase of the disease. With this information, it will be possible to identify individuals with symptoms of the disease in the CNS, particularly in the chronic phase, allowing for the proper diagnosis and treatment of these manifestations. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DAMIANO, RODOLFO FURLAN; ROCCA, CRISTIANA CASTANHO DE ALMEIDA; SERAFIM, ANTONIO DE PADUA M.; LOFTIS, JENNIFER; TALIB, LEDA LEME; PAN, PEDRO MARIO; CUNHA-NETO, EDECIO; KALIL, JORGE; DE CASTRO, GABRIELA SALIM; SEELAENDER, MARILIA F.; et al. Cognitive impairment in long-COVID and its association with persistent dysregulation in inflammatory markers. FRONTIERS IN IMMUNOLOGY, v. 14, p. 13-pg., 2023-05-23. (22/01769-5, 21/14379-8, 20/02988-7)

RODOLFO FURLAN DAMIANO; MAURÍCIO SCOPEL HOFFMANN; NATAN PEREIRA GOSMANN; PEDRO MARIO PAN; EURÍPEDES CONSTANTINO MIGUEL; GIOVANNI ABRAHÃO SALUM. Translating measurement into practice: Brazilian norms for depressive symptom assessment with the Patient Health Questionnaire (PHQ-9). Revista Brasileira de Psiquiatria, 2023-07-03. (21/14379-8)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

DAMIANO, Rodolfo Furlan. Psychopathological and cognitive manifestations associated with SARSCoV-2 virus infection. 2023. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.