Optical spectroscopic studies and triplet quantum yield determination in Tetraphenyl Porphyrins free base derivatives with distinct Chalcones side groups

• Grant number: 22/06528-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2022
• End date: December 31, 2023
• Field of knowledge: Physical Sciences and Mathematics - Physics - Condensed Matter Physics
• Principal Investigator: Leonardo de Boni
• Grantee: Carolina Salgado do Nascimento
• Host Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil

Abstract

Obtaining the spectroscopic properties as well as the fluorescence lifetimes and the determination of radiative and non-radiative rates of organic or inorganic compounds can help to describe the existence of triplet states in these. The identification of these triplet states and the determination of the quantum efficiency of singlet-triplet transfer is extremely important for applications in photonics, biophotonics, and medicine, among others. For example, the existence of accessible triplet states in organic molecules raises the possibility of applying such compounds to processes that require extra molecular energy transfer, not mediated by light. In other words, the existence of accessible triplet states in organic materials makes them a reservoir of energy (absorbed light) with a long lifetime, allowing an increase in the probability of energy transfer between different compounds via collision, which is almost impossible in the singlet states of the same. For example, one of the most efficient processes for generating singlet oxygen (reactive oxygen) is through collision, as the ground state of molecular O2 is a triplet state. Therefore, this generation can be induced through a material that absorbs light and, in its triplet state, collides with O2 molecules in the ground state, producing reactive oxygen. This is one of the main processes behind photodynamic therapy, used to treat and fight different types of cancer. In this context, the present project aims at a complex and complete optical spectroscopy study for the determination of specific properties of a new family of porphyrins, aiming to use them for dynamic phototherapy against certain types of cancer, and inactivation of bacteria and fungi.(AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TISOCO, ISADORA; KOHLER, MATEUS H.; NOGARA, PABLO A.; ROCHA, JOAO B. T.; DO NASCIMENTO, CAROLINA S.; GARCIA, RAFAEL DE Q.; DE BONI, LEONARDO; IGLESIAS, BERNARDO A.. Study on the photophysical property of meso-tetra(2-fluorenyl)porphyrin derivatives and their interactions with DNA/HSA biomacromolecules. Inorganica Chimica Acta, v. 556, p. 13-pg., 2023-06-17. (20/16036-8, 22/02439-9, 16/20886-1, 18/11283-7, 18/03758-5, 22/06561-3, 22/06528-6)