Advanced search
Start date

B-tricalcium phosphate/S53P4 scaffolds produced by direct ink writing:cold sintering and functionalization with nanoparticles

Grant number: 21/05259-9
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2022
Effective date (End): August 01, 2026
Field of knowledge:Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
Principal Investigator:Eduardo Antonelli
Grantee:Rodrigo Luiz Moraes Saldanha Oliveira
Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Federal de São Paulo (UNIFESP). Campus São José dos Campos. São José dos Campos , SP, Brazil
Associated scholarship(s):23/14247-0 - Hydrothermal sintering of 3D-printed beta-tricalcium phosphate/bioactive glass scaffolds: sintering optimization and in vitro cellular evaluation, BE.EP.DR


The use of calcium phosphate and bioactive glasses scaffolds have shown promising results on Bone Tissue Engineering to treat large bone defects. 3D printing has been drawing attention as technology to scaffolds manufacturing due to its great structural control over their geometry and for presenting high reproducibility properties. Usually, after printing, ceramic scaffolds undergo through a sintering process, in which high temperatures are employed to consolidate their structure and eliminate organic additives. Recent research have shown the possibility of sintering ceramic materials using low temperatures by combining pressure and an aqueous sintering medium to aid in the process. This method is known as cold sintering process and is being explored as an alternative to conventional sintering in several research fields, but it is still unexplored on bone tissue engineering. In addition to it, there is the possibility to ensure double function to scaffolds through a superficial treatment in order to treat bone defects affected by diseases such as osteomyelitis and Bone Cancer. Gold/platinum bimetallic nanoparticles have shown great potential in Biomedicine as antimicrobial and antitumoral agents. However, their behavior with bone cells and bone tumors is still unknown. Within this context, this work aims to study the influence of the cold sintering process in the ²-TCP/S53P4 scaffold's microstructure and properties and to study their functionalization with gold/platinum nanoparticles. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Please report errors in scientific publications list using this form.