Effect of resistance training and detraining on cognition, functional and physical performance, and brain parameters in elderly people with mild cognitive impairment.

• Grant number: 22/06777-6
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: September 01, 2022
• End date: August 31, 2024
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Marcio Luiz Figueredo Balthazar
• Grantee: Isadora Cristina Ribeiro
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology, AP.CEPID

Abstract

Mild cognitive impairment (MCI) refers to the diagnostic term applied to individuals who arebetween preserved cognitive function and dementia, which may be a precondition for thedevelopment of Alzheimer's disease (AD). Due to the predicted increase in the incidence ofAD, the importance of obtaining an early diagnosis and intervening with easily accessible toolsis highlighted to reduce investments and improve the patient's quality of life. Physical exercisewas highlighted for its positive influence on cognitive function; however, the practice ofresistance training (RT) was little investigated. The brief literature points to an improvement incognition, functionality, and physical performance of elderly people with MCI. However, somestudies contradict each other regarding brain changes and hormone concentrations related toneurodegeneration. Therefore, the aim of this study is to investigate whether resistancetraining can change the clinical trajectory of patients with MCI, evaluating possible cognitive,physical, brain and serum changes. It is intended to evaluate 60 elderly people with MCI,divided into a training group (TG, N=30) and a control group (CG, N=30) in neuropsychologicaltests, physical performance and in MRI in three moments: at the beginning of the study (TGand CG), after 24 weeks (of resistance training for the TG and control for the CG) and after 48weeks (24 weeks of detraining for the TG and another 24 weeks of control for the CG). Inaddition, both groups will be evaluated for CSF levels of AD biomarkers at the beginning of thestudy and classified and compared at the end of the study.