| Grant number: | 22/14035-0 |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| Start date: | February 01, 2023 |
| End date: | May 31, 2026 |
| Field of knowledge: | Health Sciences - Medicine |
| Principal Investigator: | Clarissa Ribeiro Reily Rocha |
| Grantee: | Izabela Amelia Marques de Andrade |
| Host Institution: | Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil |
| Associated research grant: | 19/19435-3 - The role of DNA damage and mitochondrial function in vascular, immune and neurological ageing (DNA MoVINg), AP.TEM |
| Associated scholarship(s): | 23/15341-0 - Exploring NRF2 and its target genes from a ferroptotic perspective in tumor cell lines, BE.EP.IC |
Abstract Cancer is highlighted as one of the main causes of death today, and its treatment is a worldwide concern. Therapeutic interventions have been based on radiotherapy and chemotherapy, the latter very focused on activating cell death pathways in tumorigenic cells. Despite this, chemotherapy-resistant tumors have been shown to be a complicating factor, making the treatment process difficult and reducing patient survival. In view of this scenario, acting on alternative pathways of cell death constitutes an interesting possibility for research, and in this context, ferroptosis, an iron-dependent cell death, of relatively recent discovery, can be mentioned. Investments in these spheres of study are essential and have brought to light important findings, however, most of the experiments carried out are based on cultures developed in monolayer, which, despite constituting a fundamental model, do not completely mimic important characteristics of the tumor scope, as the interaction of different parts of the tumor with the extracellular matrix. Based on previous work by the research group regarding the sensitivity of different cell lines to ferroptosis and the association of this cell death pathway with the NRF2 factor, we will seek here to comparatively analyze the cell viability of tumor lines in different culture models, under the optics of ferroptosis and resistance to chemotherapeutics. Therefore, it will be based mainly on the elaboration of two-dimensional and three-dimensional cultures of tumor lines, which will be treated with chemotherapy and ferroptosis inducers, so that the cellular responses for each model can be characterized | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
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