Screen-printed carbon electrodes for the detection of clinical and pharmaceutical compounds

• Grant number: 23/00321-3
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate (Direct)
• Start date until: May 01, 2023
• End date until: October 28, 2023
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Bruno Campos Janegitz
• Grantee: Jéssica Rocha Camargo
• Supervisor: Craig E. Banks
• Host Institution: Centro de Ciências Agrárias (CCA). Universidade Federal de São Carlos (UFSCAR). Araras , SP, Brazil
• Institution abroad: Manchester Metropolitan University (MMU), England
• Associated to the scholarship: 19/23177-0 - Development of disposable devices with conductive inks and low cost substrates for the biosensing of hormonal dysfunctions and detection of Malaria, BP.DD

Abstract

The development of versatile, inexpensive, and reproducible electrochemical sensors has increased due to these sensors can be adapted to the specific needs of the application by varying the composition and design of these systems. In this sense, devices designed as electrochemical tools can be adapted to specific needs, i.e. they can be portable, disposable, wearable, or flexible. The versatility of these devices is very important as society demands technologies that are easy to use, in real-time and at the point of need. Conductive inks are increasingly being used to make sensors, primarily due to of their design versatility, ease of fabrication, and low cost compared to other sensors. Carbon-based materials can be an excellent alternative for developing conductive inks because they are cost-effective and offer advantages such as higher electrical conductivity and a large electroactive area. Carbon Black Super P® (CBSP®) a few studied carbon-based material for the construction of disposable electrochemical sensors, which presents additives that improve conductivity and optimize electron transfer properties. Therefore, its properties are considered ideal for the production of conductive inks. In addition to the conductive material, it is also important that the polymer matrix to be used is suitable. Some works show the advantages of using polymeric vinyl matrices with carbon black. Therefore, the preparation is optimized in terms of the best ratio between CBSP® and the polymeric vinyl matrix to achieve higher conductivity of the final electrode. To improve the analytical signals, the sensor can also be modified with gold nanoparticles (AuNPs). In this sense, the present project aims to develop the SPE sensor made of a conductive Carbon Black Super P® ink for use in the diagnosis of disorders of the biomarkers melatonin and tryptophan. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVA, RAFAEL MATIAS; DA SILVA, ALEXSANDRA DIAS; CAMARGO, JESSICA ROCHA; DE CASTRO, BRUNA SANTOS; MEIRELES, LAIS MUNIZ; SILVA, PATRICIA SOARES; JANEGITZ, BRUNO CAMPOS; SILVA, TIAGO ALMEIDA. Carbon Nanomaterials-Based Screen-Printed Electrodes for Sensing Applications. BIOSENSORS-BASEL, v. 13, n. 4, p. 38-pg., 2023-04-01. (17/21097-3, 19/23177-0, 23/00321-3)