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Passiflora: interindividual variation in bioavailability of phenolic compounds and effect on metabolic response

Grant number: 22/16139-7
Support Opportunities:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): July 01, 2023
Effective date (End): October 31, 2023
Field of knowledge:Agronomical Sciences - Food Science and Technology - Food Science
Principal Investigator:Franco Maria Lajolo
Grantee:Isabella de Araújo Esteves Duarte
Supervisor: Dragan Milenkovic
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: University of California, Davis (UC Davis), United States  
Associated to the scholarship:22/05463-8 - Passiflora fruit: interindividual variables on bioavailability of phenolic compounds and effects on metabolic response, BP.PD


The insertion of fruits from native species in the market can enhance the socio-economic development of the region, in addition to valuing Brazilian biodiversity. Native passion fruit is rich in bioactive compounds associated with reducing the incidence of obesity-associated comorbidities. Our research group demonstrated that fruits of P. tenuifila, passion fruit native to the Brazilian Cerrado, are rich in phenolic compounds, mainly proanthocyanidins, and their ingestion promotes the improvement of some cardiometabolic markers. However, a large interindividual variation in the biological response is observed. Thus, considering that the biological activity attributed to these phenolic compounds depends on their absorption and metabolism, and that a great interindividual variation is observed in the bioavailability of these compounds, the objective of this work is to evaluate the bioavailability of the phenolic compounds of P. tenuifila and to study the mechanisms by which these compounds act on metabolism under a nutrigenomic approach. For this, PBMC from clinical trial volunteers with P. tenuifila consumption will be isolated for RNA extraction and analysis of global gene expression. (AU)

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