Paratypic Salmonella is efficient at carrying out the process of intestinal inflammation and taking advantage of this to win competition with other microorganisms in the gut microbiome. In mammals the process is associated with the use of tetrathionate (Ttr), a by-product of intestinal inflammation, by Salmonella spp., a process that also involves the use of propanediol (Pdu) as an energy source by the bacteria. Therefore, the inflammatory process benefits Salmonella during a complex intestinal environment, composed of diverse microorganisms, allowing the pathogen to carry out the process of intestinal colonization, as well as its dissemination to the external environment. within this process, Salmonella enterica serovar Enteritidis is among the most important serovars causing diseases in animals and humans, with an emphasis on foodborne diseases. This project proposes to analyze the immune responses of commercial birds experimentally challenged by S. Enteritidis with modifications in the genes responsible for the metabolic processes of tetrathionate (ttrA) and 1,2-propanediol (pduA) utilization, through the expression of genes related to the immune response.
News published in Agência FAPESP Newsletter about the scholarship: