Endothelial dysfunction in preeclampsia: potential drugs and new pharmacological targets obtained from of "omics" tools

• Grant number: 23/11925-7
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: November 01, 2023
• End date: November 30, 2024
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Valeria Cristina Sandrim
• Grantee: Moisés Henrique Mastella
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated research grant: 21/12010-7 - Endothelial dysfunction in hypertensive disorders of pregnancy, AP.TEM

Abstract

It is likely that the Endothelial Dysfunction (ED) found in Hypertensive Disorders of Pregnancy are evoked by the actions of multiple factors and several pathways. Then the discovery and the understanding of these converging pathways that contribute to ED and pooroutcome of pregnancy can addressing potential molecules with are modulated by different drugs. The use of omics tools, such as transcriptome and proteome, may help in this field. Importantly although the knowledge of ED in HDP and the mechanisms underlying these processes are now becoming increasingly understood, this is not corresponding to developments in drug development/uses. Thereare no investments of pharmacy industries in this field due probably to high-risk investment in pregnant treatment. Moreover, even with improvement in researches on the pathophysiology ofgestational hypertensive diseases, drug therapy remains limited and, therefore, is a contributing factorto the maintenance of high rates of maternal mortality. Therefore the current proposal will explore potential drugs and new pharmacologicaltargets obtained from "omics" tools to resolve ED in preeclampsia.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PINTO-SOUZA, CAROLINE C.; KAIHARA, JULYANE N. S.; NUNES, PRISCILA R.; MASTELLA, MOISES H.; ROSSINI, BRUNO C.; CAVECCI-MENDONCA, BRUNA; CAVALLI, RICARDO DE CARVALHO; DOS SANTOS, LUCILENE D.; SANDRIM, VALERIA C.. Different Proteomic Profiles Regarding Antihypertensive Therapy in Preeclampsia Pregnant. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 25, n. 16, p. 16-pg., 2024-08-01. (22/07605-4, 23/11925-7, 21/12010-7, 23/08897-1)

VIANA-MATTIOLI, SARAH; FONSECA-ALANIZ, MIRIAM HELENA; PINHEIRO-DE-SOUSA, IGUARACY; ROSA JUNIOR, RICARDO; MASTELLA, MOISES HENRIQUE; CAVALLI, RICARDO DE CARVALHO; SANDRIM, VALERIA CRISTINA. Plasma from hypertensive pregnancy patients induce endothelial dysfunction even under atheroprotective shear stress. SCIENTIFIC REPORTS, v. 15, n. 1, p. 15-pg., 2025-02-08. (21/12010-7, 23/11925-7, 19/07230-8)