Symptoms referred by patients diagnosed with lung, head or neck cancer and their relations with home-based physical training

• Grant number: 23/07495-7
• Support Opportunities: Scholarships in Brazil - Master
• Start date: January 01, 2024
• End date: April 30, 2025
• Field of knowledge: Health Sciences - Physiotherapy and Occupational Therapy
• Principal Investigator: Ercy Mara Cipulo Ramos
• Grantee: Matheus André Pedroso
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil

Abstract

Introduction: Physical exercise can be used as a complement to chemotherapy and/or radiotherapy, considered usual oncologic treatments (UOT) for lung, head or neck cancer, it seeks to reduce negative effects caused by the disease and the UOT. Physical exercise's effects on symptoms experienced during UOT are still not widely researched. Objectives: To verify frequency and intensity of symptoms experienced by individuals diagnosed with lung, head or neck cancer submitted to UOT concomitant or not to a home-based physical training (HBPT), assessing its efficacy in lessening these symptoms. Furthermore, the symptoms will be correlated to body composition, functional capacity, muscle strength and anxiety and depression previous to UOT, as possible predictors; Methods: A quantitative study will be conducted using a sample from a Randomized Clinical Trial (RCT), related to a Regular Project (FAPESP process number: 2021/06065-3). This RCT includes individuals diagnosed with lung, head and neck cancer with programmed UOT. These individuals are randomized in a Training Group (TG) and a Control Group (CG). The TG is submitted to HBPT concomitant to UOT. This HBPT includes aerobic training (daily walks, at least 20 minutes) and resisted training (elbow flexion, knee flexion and knee extension, twice per week, utilizing TheraBands). The CG is oriented to maintain usual activities. Referring to this master's Project, individuals in both groups will answer the Edmonton Symptom Assessment System - Brazilian version (ESAS-Br) weekly during active UOT to verify symptoms' frequency and intensity experienced in the seven days previous to the scale application. Statistical analysis: Data normality will be assessed using the Shapiro-Wilk test. The frequency of symptoms will be expressed as a percentage normalized by the weeks of active UOT for each patient. The comparison of symptom frequency and intensity between the TG and CG will be performed using the Mann-Whitney U test. Pearson's or Spearman's correlation test will be used to analyze the correlation between pre-treatment variables and symptoms. The level of significance will be set at p<0.05.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PEDROSO, MATHEUS; GRIGOLETTO, ISIS; OLIVEIRA, LETICIA; MARTINS, SARAH; COSTA, LARA; POZO, KARINA; BORGES, PALOMA; REGIO, LIVIA; DUARTE, ISABELA; CAVALHERI, VINICIUS; et al. Adherence to Exercise in People with Lung or Head and Neck Cancer: Self-Reported Symptoms and Motivation During Cancer Treatment Need to Be Considered. JOURNAL OF CLINICAL MEDICINE, v. 13, n. 20, p. 12-pg., 2024-10-01. (23/07495-7, 21/04233-6, 21/06065-3, 19/16004-1, 22/04801-7)