Obesity and overweight as risk factors for recurrent gallstone disease after cholecystectomy in young patients: retrospective study according to the presence of low-phispholipid associated colecistopathy.

• Grant number: 24/12608-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2024
• End date: September 30, 2025
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Fernando Gomes Romeiro
• Grantee: Jady de Oliveira Carvalho
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Introduction: Gallstone disease is a huge health problem that tends to growth with the increasein obesity, overweight and other risk factors such as sedentary lifestyle and Western diet. Oneof the less common causes is low phospholipids associated cholelithiasis (LPAC), caused by agenetic mutation and diagnosed by the presence of at least two of three criteria: symptomaticcholelithiasis before 40 years, recurrence after cholecystectomy, and intrahepatic gallstones.Aim: To retrospectively evaluate the prevalence of recurrent gallstone disease in young patientswho were submitted to cholecystectomy at the Hospital das Clínicas of the Faculty of Medicineof Botucatu/UNESP (HC-FMB/UNESP) in the last 12 years, assessing the contribution of eachrisk factor for gallstone disease in this population and focusing on obesity and overweight.Methods: A survey of cholecystectomy cases before 40 years will be carried out in the HC-FMB/UNESP hospital complex, identifying those who had recurrence of cholelithiasis after thesurgery, requiring endoscopic retrograde cholangiopancreatography (ERCP). The cases will bedivided between those with non-genetic risk factors (mainly female gender, obesity andoverweight) from the ones in whom the genetic factor is more probable. Thus, the sample willbe divided into likely LPAC and unlikely LPAC, and the contribution of the non-genetic riskfactors will be analyzed in both groups. Statistical analysis: Poisson regression will beperformed, in which recurrent lithiasis will be the outcome and non-genetic risk factors will bediscrete variables. Each group will be separately evaluated. Expected results: It is expected toadequately estimate the LPAC prevalence and the effect of each risk factor for recurrentgallstone disease in young patients, both in cases of LPAC and others. It is also expected todiagnose LPAC patients properly, giving them the appropriate treatment and avoiding newadmissions due to recurrence.