Scholarship 24/07538-0 - Fungos, Metabólitos secundários - BV FAPESP
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Modulation of a wound healing agent biosynthesis by a fungal species isolated from the Caatinga biome

Grant number: 24/07538-0
Support Opportunities:Scholarships in Brazil - Master
Start date until: November 01, 2024
End date until: July 31, 2026
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Ana Olívia de Souza
Grantee:Ana Carolina da Matta
Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Fungi produce a wide variety of secondary metabolites that may have distinct pharmacological properties. Although many biosynthetic gene clusters responsible for encoding the expression of these metabolites can be silenced under laboratory culture conditions, the epigenetic modulation is a promising strategy to increase the production of specific metabolites, or promote the biosynthesis of new compounds. In a previous study, an alpha-pyrone derivative produced by a species of an endophytic fungus from the Caatinga biome was effective in repair, regenerate and tissue remodeling in the wound healing process in a murine model. Continuing the previous study, this project aims to modify the culture conditions (pH, temperature and agitation) of the fungus including the addition of epigenetic modifiers such as inhibitors of histone deacetylases (HDAC) and DNA methyltransferases (DNMT) for the activation of silent biosynthetic genes and definition of the best condition to increase the production of the metabolite of interest.

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