AGING EFFECT ON APOPTOSIS AND INFLAMMATORY EARLY MARKERS AFTER INFLUENZA VACCINATION

• Grant number: 23/16851-1
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Start date: March 01, 2025
• End date: May 31, 2025
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Alberto José da Silva Duarte
• Grantee: Juliana Ruiz Fernandes
• Supervisor: Holden Maecker
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: Stanford University, United States
• Associated to the scholarship: 22/04632-0 - Immunossenescence and vacinas response: impact of age on the T and B lymphocytes response to SARS-CoV-2 after additional dose of COVID-19 vaccine, BP.PD

Abstract

Human life expectancy has significantly increased, attributed to medical and technological advances, particularly vaccines. However, influenza remains a public health challenge, especially among the elderly due to immunosenescence-the aging-related decline in immune function. This project explores immunosenescence-related changes in various immune components and their impact on influenza vaccine efficacy. The study aims to evaluate apoptosis and inflammatory markers in serum samples from young adults and the elderly after trivalent inactivated influenza vaccine (TIV) administration. The correlation between these markers, age, and influenza antibody titers will be assessed. Approximately 50 serum samples from young adults and the elderly, on day 0 and day 1 post-vaccination, will be analyzed using Luminex technology. Various inflammatory and apoptosis markers will be measured, providing a comprehensive immune profile. Despite advancements, current influenza vaccines face challenges in providing effective protection for older adults. The project discusses limitations and proposes strategies for improving vaccine efficacy. Given the profound impact of aging on the immune system, understanding the interplay between aging, immunity, and vaccines is crucial. Technological advancements enable in-depth immune profiling, providing valuable insights into vaccine responses. In conclusion, this project tackles crucial aspects of immunosenescence and vaccine responses, aiming to enhance our understanding and improve vaccination strategies for the elderly. The collaboration with Stanford University enriches the research with advanced methodologies and fosters knowledge exchange for broader scientific impact.