Impact of sexual dimorphism on experimental colitis

• Grant number: 24/20758-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: January 01, 2025
• End date: December 31, 2025
• Field of knowledge: Biological Sciences - Immunology - Applied Immunology
• Principal Investigator: Cristina Ribeiro de Barros Cardoso
• Grantee: Amanda Soares França
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 23/03257-4 - The interplay between SARS-CoV-2 infection and dysregulated gut immunity, AP.TEM

Abstract

The interaction between pre-existing intestinal inflammation and gut health is a topic of growing interest, especially regarding potential sex-specific differences. This undergraduate research activity aims to investigate the impact of colitis and its differences in the intestines of male and female mice. The study will use dextran sulfate sodium (DSS) to induce colitis and examine whether sex differences influence responses in mouse models. By exploring these interactions, we aim to gain insights into potential sex-related immune responses and their involvement in gut health, in order to guide further studies of the thematic project.