N-Heterocyclic Side chains in The Rational Design of Novel Aminocatalysts

• Grant number: 25/19623-5
• Support Opportunities: Scholarships in Brazil - Master
• Start date: October 01, 2025
• End date: September 30, 2027
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Bruno Matos Paz
• Grantee: Julia Yumi Fontes Jamatto
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 22/14310-0 - Linear free energy relationships in asymmetric catalysis, AP.JP

Abstract

Novel aminocatalysts will be designed based on diarylprolinol silyl ether (Jørgensen-Hayashi) and imidazolidinones (MacMillan) provileged scaffolds, both bearing N-heterocyclic side-chains. Also, kinetic studies will be performed aiming to obtain structure-activity studies correlating kinetic, electronic and acid-base Properties as well as Linear Free Energy Relationships. (AU)