Association of the 16S Microbiome with NETosis in Canine Mammary Carcinoma and Its Impact on the Modulation of NETosis

• Grant number: 26/00276-6
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: March 01, 2026
• End date: February 29, 2028
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Pathology
• Principal Investigator: Noeme Sousa Rocha
• Grantee: Carlos Mario Gonzalez-Zambrano
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated research grant: 24/16211-5 - ASSOCIATION OF 16S MICROBIOME WITH NETOSIS IN CANINE BREAST CARCINOMA AND ITS IMPACT ON NETOSIS MODULATION, AP.R

Abstract

This study investigates the interaction between the 16S microbiome and mammary carcinoma, as well as explores the effects of microbiome modulation on the NETosis mechanism. Using a detailed methodology, fecal samples and oral swabs will be collected from female dogs with mammary carcinoma for 16S microbiome analysis. The research aims to elucidate the underlying mechanisms of the immune response and its interaction with the microbiome. The hypothesis posits that the composition and diversity of the microbiome are altered in female dogs with mammary carcinoma, which in turn affects the activation of NETosis mechanisms. The objectives include microbiome characterization, quantification of NETosis, and evaluation of the impact of microbiome modulation on the immune response. These investigations may provide valuable insights for the treatment of mammary carcinoma in dogs and potential clinical applications in humans. (AU)