Repair of rabbits calvaria bone defects using bioactive glass-ceramic: biosilicate

• Grant number: 09/17294-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: March 01, 2010
• End date: February 28, 2011
• Field of knowledge: Health Sciences - Dentistry - Oral and Maxillofacial Surgery
• Principal Investigator: Mariza Akemi Matsumoto
• Grantee: Gustavo Caviquioli
• Host Institution: Centro de Ciências Biológicas e Profissões da Saúde. Universidade do Sagrado Coração (USC). Bauru , SP, Brazil

Abstract

A number of methods have been studied in order to reduce the period of bone repair, as well as to offer less invasive treatments minimizing morbidity related to large reconstructive procedures. In this way, various biomaterials are been developed in order to act as bone substitutes, presenting clinical and biological satisfactory results. The aim of the present study is to evaluate the biological behavior of a new bioactive glass-ceramic (Biosilicato®) as filling material in bone defects alone and associated to autogenous bone graft. Bilateral bone defects will be performed in rabbit calvaria, presenting diameter of 10mm. Thirty male New Zealand rabbits will compound four groups: Group 1) bone defects filled with blood clot, Group 2) bone defects filled with particulate autogenous bone grafts, Group 3) bone defects filled with bioactive glass-ceramic (Biosilicato®), and Group 4) bone defects filled with bioactive glass-ceramic (Biosilicato®) and particulate autogenous bone graft. The animals will be sacrificed after 7, 14 and 30 days in order to retrieve of specimens that will be submitted to histotechnical procedures permitting histological and histomorphometric analysis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VIVAN, RODRIGO RICCI; MECCA, CARLOS EDUARDO; BIGUETTI, CLAUDIA CRISTINA; MUNIZ RENNO, ANA CLAUDIA; OKAMOTO, ROBERTA; CAVENAGO, BRUNO CAVALINI; DUARTE, MARCO HUNGARO; MATSUMOTO, MARIZA AKEMI. Experimental maxillary sinus augmentation using a highly bioactive glass ceramic. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v. 27, n. 2, FEB 2016. (09/17294-1)

BIGUETTI, CLAUDIA CRISTINA; CAVALLA, FRANCO; TIM, CARLA ROBERTA; SARAIVA, PATRICIA PINTO; ORCINI, WILSON; HOLGADO, LEANDRO DE ANDRADE; MUNIZ RENNO, ANA CLAUDIA; MATSUMOTO, MARIZA AKEMI. Bioactive glass-ceramic bone repair associated or not with autogenous bone: a study of organic bone matrix organization in a rabbit critical-sized calvarial model. CLINICAL ORAL INVESTIGATIONS, v. 23, n. 1, p. 413-421, JAN 2019. (09/17294-1)

MATSUMOTO, MARIZA AKEMI; CAVIQUIOLI, GUSTAVO; BIGUETTI, CLAUDIA CRISTINA; HOLGADO, LEANDRO DE ANDRADE; SARAIVA, PATRICIA PINTO; MUNIZ RENNO, ANA CLAUDIA; KAWAKAMI, ROBERTO YOSHIO. A novel bioactive vitroceramic presents similar biological responses as autogenous bone grafts. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v. 23, n. 6, p. 1447-1456, JUN 2012. (09/17294-1)