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Lifestyle factors, diet, family history of cancer and the risk of head and neck cancer in young adults

Grant number: 10/09661-1
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): September 01, 2010
Effective date (End): August 31, 2013
Field of knowledge:Health Sciences - Collective Health - Epidemiology
Principal Investigator:Victor Wünsch Filho
Grantee:Tatiana Natasha Toporcov
Home Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The incidence and mortality of Head and Neck Cancer (HNC) among young adults (less than 46 years old) increased during the last decades. Some authors argue that HNC etiology may differ for young adults and older patients. The study of HNC risk factors for young adults may contribute to the etiological knowledge of the disease. This study aimed at assessing the contribution of behavioral exposures and family history of cancer on HNC in people aged less than 46 years older. This study will gather data from 26 case-control studies that joined the International Head and Neck Cancer Epidemiology Consortium (INHANCE - International Agency for Research on Cancer). This Consortium comprises 18,694 cases of HNC and 26,673 controls, corresponding to 1439 cases and 3099 controls among young adults eligible to this study. Inter-study heterogeneity was previous evaluated and data from the 26 INHANCE studies were considered to be comparable. This study will assess the role of tobacco smoking, alcohol drinking, consumption of fruit and vegetables, and family history of cancer on HNC etiology. Analyses will be stratified by site, sex and age group. (AU)