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Evaluation of hidrossolubility and stability of rutin's microcapsules, obtained by molecular inclusion and coacervation

Grant number: 09/06650-1
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2009
Effective date (End): July 31, 2010
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal Investigator:Rodney Alexandre Ferreira Rodrigues
Grantee:Vivian Schultz Peres
Host Institution: Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA). Universidade Estadual de Campinas (UNICAMP). Paulínia , SP, Brazil


Rutin is an important bioflavonoids known for their antiallergic properties, anti-inflammatory, antimicrobial, normalizes the resistance and permeability of the wall of capillary vessels in addition to antioxidant properties. However, its low solubility in water is a barrier to its use and marketing, primarily for the pharmaceutical area. In the experimental part, will be held on microencapsulation of rutin, obtained from fava-d'anta, a flavonoid widely used in industry with several pharmacological properties, such as increased vascular permeability, hypolipidemic action, decrease blood glucose and anti-oxidant properties. The choice of rutin is because of that comes from a species of wide occurrence in regions of Brazilian' Cerrado and Caatinga, biomes considered with a high degree of extinction of its species, therefore, can justify the use of the plant as a source of flavonoid in studies of dosmetication. This work will aim rutin's microencapsulation by the methods of molecular inclusion with ²-cyclodextrin, and coacervation using biopolymers as the Acacia gum and gelatin. A comparison between the rutin encapsulated by these two methods and rutin not encapsulated will be performed to evaluate the improvement in water solubility and study its stability for a period of 60 days (samples every 10 days), before exposure to light, at 700 lux, and temperature and humidity controlled (45 ° C and 75% ERH). The determination of the content of rutin awill be made by spectrophotometry in the UV-Vis at 398 nm.

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