Evaluation of risk of coronary heart disease in postmenopausal women.

• Grant number: 09/15659-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): February 01, 2010
• Effective date (End): January 31, 2011
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Eliana Aguiar Petri Nahás
• Grantee: Aline Maia de Andrade
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Cardiovascular disease (CVD), especially coronary artery disease (CAD), comprises the main cause of mortality in postmenopausal women. CHD is caused by the atherosclerotic process of progressive evolution, which involves a number of risk factors such as hypercholesterolemia, smoking, hypertension, diabetes, stress, inactivity and obesity, which cannot be ignored in the approach to climacteric women. Through the estimation of risk, we can suggest the establishment of priority measures for primary and secondary prevention, in an attempt to reduce the occurrence of CAD. However, the detection of early markers would allow the recognition of subclinical atherosclerotic disease with early intervention on modifiable risk factors, important in management of post-menopausal women. Atherosclerosis is a disease of the arterial wall, characterized by inflammation and remodeling that can manifest as acute vascular event, becoming clinically apparent. In CAD, conventional risk factors remain important, but individual differences in immune profile may modulate the severity of the atherosclerotic process. The aim of this scientific research will be to estimate the percentage of the absolute risk of developing CAD in women after menopause through the Framingham risk score. With the project expected to identify patients at cardiovascular risk thus proposing preventive measures effective in reducing the occurrence of manifest disease leading cause of mortality in this population, affecting considerably the quality of life in menopause.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NAHAS, ELIANA A. P.; ANDRADE, ALINE M.; JORGE, MAYRA C.; ORSATTI, CLAUDIO L.; DIAS, FLAVIA B.; NAHAS-NETO, JORGE. Different tools for estimating cardiovascular risk in Brazilian postmenopausal women. Gynecological Endocrinology, v. 29, n. 10, p. 921-925, OCT 2013. (09/15659-2)