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Study of methylene beta-ketoesters reduction by microorganisms

Grant number: 05/00946-5
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): August 01, 2005
Effective date (End): February 28, 2006
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:José Augusto Rosário Rodrigues
Grantee:Giuliano Cesar Clososki
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

We intend to investigate the mono and the double direct methylenation of ,-ketoesters and to study the reduction of the C=C bond and the carbonyl of various ketones. Suitable yeast will be used as biocatalysts which are available in Brazilian culture collections to carry out asymmetric reductions of enones to generate two or three stereogenic centers. The biocatalysts should be selected in accord to their capacity to perform the transformations giving compounds with high enantiomeric purity. The main motivation is to find synthetic alternatives to obtain synthetic intermediates that could be used in the synthesis of molecule with relevant pharmacological properties, which have been prepared by asymmetric aldol reactions.

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