Potential action of Isatin-Schiff base complexes and derivatives on oxidative stress: a chemical bond study

• Grant number: 07/04379-3
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Effective date (Start): November 01, 2007
• Effective date (End): February 16, 2009
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Ana Maria da Costa Ferreira
• Grantee: Giovanni Finoto Caramori
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The purpose of this work is to perform a comprehensive investigation on the chemical bonds of complexes that contain oxindol derivatives as ligands, including mainly Cu(II) complexes, which present pro-apoptotic activities. This study will explore the nature of the metal-ligand bonds. Not only different ligands but also diferent metals will be considered. In addition, this work proposes a theoretical analysis about the ability of these complexes to produce ROS through the Haber-Weiss reaction. Furthermore, this work will also investigate the main interaction between the above mentioned complexes with enzymatic (interactions of complexes with amino acids of the catalytic site) and non-enzymatic antioxidants, responsible to the detoxification of ROS. The aim of this work is to correlate the different chemical bonding situations, which depends on the nature of transition metals and ligands, with the pro-apoptotic activities observed experimentally. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GIOVANNI FINOTO CARAMORI; KLEBER THIAGO DE OLIVEIRA. Aromaticidade: evolução histórica do conceito e critérios quantitativos. Química Nova, v. 32, n. 7, p. 1871-1884, 2009-00-00. (07/04379-3)

PARREIRA, RENATO L. T.; CARAMORI, GIOVANNI F.; GALEMBECK, SERGIO E.; HUGUENIN, FRITZ. The Nature of the Interactions between Pt-4 Cluster and the Adsorbates H-center dot, (OH)-O-center dot, and H2O. Journal of Physical Chemistry A, v. 112, n. 46, p. 11731-11743, NOV 20 2008. (07/04379-3, 05/00106-7)

CARAMORI, GIOVANNI F.; PARREIRA, RENATO L. T.; DA COSTA FERREIRA, ANA MARIA. Isatin-Schiff base copper(II) complexes-A DFT study of the metal-ligand bonding situation. International Journal of Quantum Chemistry, v. 112, n. 2, p. 625-646, JAN 15 2012. (05/60596-8, 07/04379-3)