Use of electrochemical sensors for genotoxicity investigations.

• Grant number: 08/04209-3
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date until: July 01, 2008
• End date until: March 31, 2011
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Lauro Tatsuo Kubota
• Grantee: Danielle Cristhina Melo Ferreira
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

An area of great relevance in Brazil is addressed to genotoxicity, where need to be explored. The biosensors application as a simple, fast, sensitive, selective reproducible, and possible to mimetize what happens at pharmacological levels, is interesting and already is being carried out in some international groups. Thus, this project proposes the development od biosensors in this area, mainly in detection of DNA damages, as to be applied to diagnosis and characterization of oxidative damage or other type involving DNA by quinones (for examples alpha and beta lapachones and juglones, and nitroaromatics like metronidazol and niclosamide). In the same way, anti-oxidant substances becomes relevant in these processes. Based on these ir pretended to perform new focus in the medicinal chemistry and electrochemistry, acquiring new capability in bioelectrochemical and ultramicroelectrode technique in the development of useful tools to compare hybridization of these devices and molecular biology to select important compounds. Thus, making possible to have new expert in this area and generating patent and products.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VIDOTTI, MARCIO; CARVALHAL, RAFAELA F.; MENDES, RENATA K.; FERREIRA, DANIELLE C. M.; KUBOTA, LAURO T.. Biosensors based on gold nanostructures. Journal of the Brazilian Chemical Society, v. 22, n. 1, p. 3-20, 2011. (08/04209-3)