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Use of electrochemical sensors for genotoxicity investigations.

Grant number: 08/04209-3
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): July 01, 2008
Effective date (End): March 31, 2011
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal researcher:Lauro Tatsuo Kubota
Grantee:Danielle Cristhina Melo Ferreira
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


An area of great relevance in Brazil is addressed to genotoxicity, where need to be explored. The biosensors application as a simple, fast, sensitive, selective reproducible, and possible to mimetize what happens at pharmacological levels, is interesting and already is being carried out in some international groups. Thus, this project proposes the development od biosensors in this area, mainly in detection of DNA damages, as to be applied to diagnosis and characterization of oxidative damage or other type involving DNA by quinones (for examples alpha and beta lapachones and juglones, and nitroaromatics like metronidazol and niclosamide). In the same way, anti-oxidant substances becomes relevant in these processes. Based on these ir pretended to perform new focus in the medicinal chemistry and electrochemistry, acquiring new capability in bioelectrochemical and ultramicroelectrode technique in the development of useful tools to compare hybridization of these devices and molecular biology to select important compounds. Thus, making possible to have new expert in this area and generating patent and products.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VIDOTTI, MARCIO; CARVALHAL, RAFAELA F.; MENDES, RENATA K.; FERREIRA, DANIELLE C. M.; KUBOTA, LAURO T. Biosensors Based on Gold Nanostructures. Journal of the Brazilian Chemical Society, v. 22, n. 1, p. 3-20, 2011. Web of Science Citations: 57.

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