Compounds with furanofurones and piranopirones frameworks from disacharides: synthetic studies

• Grant number: 10/12701-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2010
• End date: September 30, 2011
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Lúcia Helena Brito Baptistella
• Grantee: Luiz Fernando Toneto Novaes
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 09/51602-5 - Chemical biology: new natural and synthetic molecular targets against cancer, structural studies, biological evaluation and mode of action, AP.TEM

Abstract

This project refers to the exploration of synthetic methods for the transformation of lactose, an abundant natural disaccharide, in bicyclic lactones systems with furanofurone and furanopirone skeletons. These molecules present a great interest for biological activity studies, especially due to their structural similarity with other bicycles with known cytotoxic action, as exemplified by the styryl lactones. In this synthetic route, we want to explore stereo-and regioselective reactions.