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EFFECTS OF TRAMADOL, ASSOCIATED OR NOT TO XYLAZINE IN HORSES

Grant number: 08/01550-6
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2008
Effective date (End): May 31, 2009
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal Investigator:Antonio de Queiroz Neto
Grantee:Anelize Santi Milaré
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil

Abstract

The control of pain, despite the great progress of science, remains a constant concern among clinicians and pharmacologists. In animals in general, and in horses, in particular, due its often violent reaction to a stressful stimulus, an adequate analgesia becomes even more important. Many drugs are available for treatment of pain, and several techniques are used to maximize their effects. One of the best strategies for pain control results from the combination of drugs that act by different mechanisms. This increases the analgesic effect and reduces the side effects of each drug alone by using lower doses of each one. This synergistic effect is often achieved by the association of opioids and tranquilizers, procedure known as neuroleptanalgesia. In horses, this procedure is still more important because of the frequent excitatory effect that usually happens after opioid administration, which is prevented by the use of tranquilizers. Tramadol is an opioid with analgesic potency similar to that of morphine, which has been, for decades, used in humans, and more recently in dogs. In horses, the few publications on its use (especially parenteral not spinal) are quite controversial. Its action seems to involve several mechanisms, among them, there is broad consensus on the participation of opioid type ¼, and ±2 adrenergic receptors. The purpose of this project is to study the effects of three doses of tramadol associated or not with xylazine on locomotor activity and head height (measures of excitability) and also on the nociception by means of thermal stimulation.