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Experimental asthma induced by Blomia tropicalis: modulation by immunological tolerance or by agonists of toll-like receptors 4

Grant number: 05/00654-4
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): October 01, 2005
Effective date (End): January 31, 2006
Field of knowledge:Biological Sciences - Immunology
Principal researcher:Momtchilo Russo
Grantee:Alexandre de Castro Keller
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:04/14297-6 - Activation/deactivation of macrophages and CD4+ T lymphocytes in experimental asthma, AP.TEM

Abstract

Sensitization to ovalbumin (OVA) with Alum and intranasal OVA challenge became one of the most explored murine models of asthma. An alternative approach for murine asthma model is the use of allergens commonly associated with human asthma or atopy. Blomia tropicalis (Bt) is a mite ubiquitous in tropical countries and is strongly related with allergy. However, most of the studies concerning Bt sensitization usually focused on skin tests or on the production of anaphylactic antibodies. Experimentally, very little is known about asthma induction by Bt. In addition, there are few studies addressing the possible modulation of allergic responses induced by Bt.In my studies I used OVA as allergen to study the modulation of experimental asthma by immunological tolerance or by TLR4 activation. The aim of the present project is to investigate the ability of these two immunoregulatory mechanisms to modulate Bt-induced experimental asthma. We have already characterized a model of Bt-induced asthma that reproduces, in different mice strains, the most important asthma-like phenotypes.

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