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Molecular pathogenesis and clinical consequences of the infections caused by the human parvovirus B19 and Human Cytomegalovirus among patients with hemaglobinopathies and haemophilia

Grant number: 09/16623-1
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): April 01, 2010
Effective date (End): March 31, 2013
Field of knowledge:Biological Sciences - Genetics
Principal Investigator:Dimas Tadeu Covas
Grantee:Svetoslav Nanev Slavov
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Increased recognition of Parvovirus B19 (B19) and Cytomegalovirus (CMV) as human pathogens causing severe diseases in immunocompromised patients has resulted in intensive efforts to understand their pathogenesis, to improve the diagnostic algorithms that are applied in the monitoring of high-risk patients and blood products as well as to elucidate the nature of the genomic mutations that could lead to a serious diseases and organ dysfunction. While many efforts are concentrated in clarifying above mentioned problems among patients with various transplantations or immune deficiencies, up to day there is limited data for the behaviour of these two viral agents among patients with haemoglobinopathies and haemophilia. These patients present specific cohort, which is highly susceptible to opportunistic viral infections due to the impaired function of the immune system leading in most of the cases to serious consequences. The development of new diagnostic as well as sequencing approaches would reveal specific aspects of the molecular pathogenesis of parvovirus B19 and the Cytomegalovirus (CMV) among patients with haemaglobinopathies and hemophilia and would help the clinicians for the fight against severe complications induced by these agents.

Scientific publications (12)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SLAVOV, SVETOSLAV N.; MACONETTO, JULIANA D. M.; MARTINEZ, EDSON Z.; SILVA-PINTO, ANA CRISTINA; COVAS, DIMAS T.; EIS-HUEBINGER, ANNA MARIA; KASHIMA, SIMONE. Prevalence of hepatitis E virus infection in multiple transfused Brazilian patients with thalassemia and sickle cell disease. Journal of Medical Virology, v. 91, n. 9, p. 1693-1697, SEP 2019. Web of Science Citations: 0.
SLAVOV, SVETOSLAV N.; RODRIGUES, EVANDRA S.; SAUVAGE, VIRGINIE; CARO, VALERIE; DIEFENBACH, CRISTIANE F.; ZIMMERMANN, ANA M.; COVAS, DIMAS T.; LAPERCHE, SYRIA; KASHIMA, SIMONE. Parvovirus B19 seroprevalence, viral load, and genotype characterization in volunteer blood donors from southern Brazil. Journal of Medical Virology, v. 91, n. 7, p. 1224-1231, JUL 2019. Web of Science Citations: 0.
SLAVOV, SVETOSLAV NANEV; SILVEIRA, ROBERTA MARANINCHI; RODRIGUES, EVANDRA STRAZZA; DIEFENBACH, CRISTIANE FRACAO; ZIMMERMANN, ANA MARIA; COVAS, DIMAS TADEU; KASHIMA, SIMONE. Human pegivirus-1 pegivirus-1 (HPgV-1, GBV-C) RNA prevalence and genotype diversity among volunteer blood donors from an intra-hospital hemotherapy service in Southern Brazil. TRANSFUSION AND APHERESIS SCIENCE, v. 58, n. 2, p. 174-178, APR 2019. Web of Science Citations: 1.
SLAVOV, SVETOSLAV NANEV; FERREIRA, FERNANDO URSOLI; RODRIGUES, EVANDRA STRAZZA; GOMES, ROGERIO; COVAS, DIMAS TADEU; KASHIMA, SIMONE. Simultaneous zika and dengue serotype-4 viral detection and isolation from a donor plasma unit. JOURNAL OF VECTOR BORNE DISEASES, v. 56, n. 2, p. 166-169, APR-JUN 2019. Web of Science Citations: 0.
SLAVOV, SVETOSLAV N.; HESPANHOL, MARTA R.; RODRIGUES, EVANDRA S.; LEVI, JOSE E.; UBIALI, EUGENIA M. A.; COVAS, DIMAS T.; KASHIMA, SIMONE. Zika virus RNA detection in asymptomatic blood donors during an outbreak in the northeast region of Sao Paulo State, Brazil, 2016. Transfusion, v. 57, n. 12, p. 2897-2901, DEC 2017. Web of Science Citations: 10.
SLAVOV, SVETOSLAV NANEV; OTAGUIRI, KATIA KAORI; SMID, JERUSA; PENALVA DE OLIVEIRA, AUGUSTO CESAR; CASSEB, JORGE; MARTINEZ, EDSON ZANGIACOMI; COVAS, DIMAS TADEU; EIS-HUEBINGER, ANNA MARIA; KASHIMA, SIMONE. Human Parvovirus 4 Prevalence Among HTLV-1/2 Infected Individuals in Brazil. Journal of Medical Virology, v. 89, n. 4, p. 748-752, APR 2017. Web of Science Citations: 0.
SLAVOV, SVETOSLAV NANEV; OTAGUIRI, KATIA KAORI; PINTO, MARIANA TOMAZINI; VALENTE, VANDERLEIA BARBARO; AMORIM UBIALI, EUGENIA MARIA; COVAS, DIMAS TADEU; KASHIMA, SIMONE. Prevalence of Trypanosoma Cruzi antibodies in blood donors from the Sao Paulo State, Brazil, between 2012 and 2014. JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, v. 11, n. 3, p. 277-281, MAR 2017. Web of Science Citations: 3.
SLAVOV, SVETOSLAV; MATSUNO, ALESSANDRA; YAMAMOTO, APARECIDA; OTAGUIRI, KATIA; CERVI, MARIA; COVAS, DIMAS; KASHIMA, SIMONE. Zika virus infection in a pediatric patient with acute gastrointestinal involvement. PEDIATRIC REPORTS, v. 9, n. 4, p. 78-80, 2017. Web of Science Citations: 0.
SLAVOV, S. N.; OTAGUIRI, K. K.; KASHIMA, S.; COVAS, D. T. Overview of Zika virus (ZIKV) infection in regards to the Brazilian epidemic. Brazilian Journal of Medical and Biological Research, v. 49, n. 5 2016. Web of Science Citations: 32.
SLAVOV, S. N.; VILAR, F. C.; WAGATSUMA, V. M. D.; SANTANA, R. C.; MACHADO, A. A.; DA FONSECA, B. A. L.; KASHIMA, S.; COVAS, D. T. Late emergence of A594V and L595W mutations related to ganciclovir resistance in a patient with HCMV retinitis and long-term HIV progression. Brazilian Journal of Medical and Biological Research, v. 48, n. 9, p. 777-781, SEP 2015. Web of Science Citations: 2.
SLAVOV, SVETOSLAV N.; KASHIMA, SIMONE; WAGATSUMA, VIRGINIA M. D.; SILVA-PINTO, ANA CRISTINA; MARTINEZ, EDSON Z.; FAVARIN, MARIA DO CARMO; COVAS, DIMAS T. Glycoprotein B Genotyping of Human Cytomegalovirus Strains Isolated from Brazilian Patients with Sickle Cell Disease and Beta-Thalassemia Major. VIRAL IMMUNOLOGY, v. 28, n. 2, p. 123-129, MAR 1 2015. Web of Science Citations: 2.
SLAVOV, SVETOSLAV NANEV; OTAGUIRI, KATIA KAORI; MACEDO, MAYRA DORIGAN; ROCHA-JUNIOR, MAURICIO CRISTIANO; SILVA-PINTO, ANA CRISTINA; KASHIMA, SIMONE; COVAS, DIMAS TADEU. No evidence of xenotropic murine leukemia virus-related virus infection in Brazilian multiply transfused patients with sickle cell disease and beta-thalassemia major. NEW MICROBIOLOGICA, v. 37, n. 4, p. 543-550, OCT 2014. Web of Science Citations: 1.

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