Preparation of Morita-Baylis-Hillman intermediate chiral adducts for synthesis of pyrrolizidine and indolizidine alkaloids

• Grant number: 06/00842-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2006
• End date: December 31, 2006
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Fernando Antonio Santos Coelho
• Grantee: Tiago de Angelis Cordeiro
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

This undergraduated project has as purpose the preparation of chiral Baylis-Hillman adducts, from chiral aminoaldehydes and use these adducts as substrate for the synthesis of the functionalized skeletons of pyrrolizidinic and indolizidinics alkaloids. Depending on the available time, I intend to synthesize a representative example of an alkaloid of one of the class. (AU)