Synthetic uses and design of new catalyst for a asymmetric Morita-Baylis-Hillman reaction

• Grant number: 09/09031-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: November 01, 2009
• End date: October 31, 2012
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Fernando Antonio Santos Coelho
• Grantee: Manoel Trindade Rodrigues Junior
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

This pos-gratuated research project has as proporse the development of a new synthetic approach for the preparation of Monatin, a protein derivative natural sweetener showing a high sweet activity. The synthetic plan is based on the utilisation of ketoesters prepared via a Heck reaction of a chiral Morita-Baylis-Hillman adduct. This research project has also as purpose the synthesis of new ionic liquids to be used as catalyst in a asymmetric version of the Morita-Baylis-Hillman reaction. (AU)