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Grant number: 09/17561-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2011
Effective date (End): July 31, 2012
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Sonia Maria Rolim Rosa Lima
Grantee:Camila Pinho Brasileiro Martins
Home Institution: Faculdade de Ciências Médicas da Santa Casa de São Paulo (FCMSCSP). Fundação Arnaldo Vieira de Carvalho. São Paulo , SP, Brazil


INTRODUCTION: Sexuality is an essential part of each human being's personality: it exercises influence on thoughts, feelings, actions and integration. Consequently, it influences the physical and mental health. It is estimated that 43% of all women present at least one complaint about sexual problems. The disturbances in desire and arousal are among the most commonly presented clinical gynecology problems. Medicinal plants have been utilized for therapeutic purposes for millions of years, where many of such plants have been described for having aphrodisiac properties. The Tribulus terrestris is a medicinal plant native from India, which its active principle is protodioscin. It is recommended for the treatment against infertility, low libido and sexual impotence. While the effects of the estrogen in the neuroendocrine and trophism of genital organs have been well established, the contribution of androgens to the female physical and mental well-being is still a subject of discussion. Women after menopause present a 30% reduction in the levels of testosterone circulation when compared to the pre-menopause period. Many studies suggest that Tibolone can improve the sexual function, as it presents estrogenic, progestogenic and adrogenic properties. The improvement of the libido with Tibolone's therapy is plausible due to the demonstrated fact that testosterone increases the libido and the frequency of sexual activity. OBJECTIVE: 1) Study the effects of Tribulus terrestris in women presenting sexual dysfunction in the post menopause's period. 2) Study the effects of Tibolone in women presenting sexual dysfunction in the post menopause's period. 3) Conduct a comparative study of both groups. METODOLOGY: The study will be prospective, randomized and double-blind, where general anamnesis and sexual response evaluation questionnaires will be administrated. The research will take place in the Santa Casa de Misericórdia of São Paulo's Phytomedication Clinic, in a population of 90 women in the post menopause's period presenting sexual desire's dysfunction. After having identified the presence of dysfunction, the anamnesis will be conducted, physical exam and questionnaires will be conducted, and samples will be taken for routine laboratory exams. The women will be separated into three groups of 30, where one of the groups will receive Tribulus terrestris (750 mg per day) during a period of three months, the second will receive Tibolone (2,5 mg per day) and the third group will receive a placebo, during the same period. After this, women will have the questionnaires again and the laboratory exams will be repeated. EXPECTED RESULTS: Improvement of sexual desire's dysfunction in the women' groups treated with Tribulus terrestris and Tibolone's therapy. After the end of the research, the study will be prepared for publication in the magazine QUALIS A, whether the end results are favorable or not.