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3D body scan to diagnose obesity and assess cardiovascular risk

Grant number: 08/03714-6
Support type:Scholarships abroad - New Frontiers
Effective date (Start): October 13, 2008
Effective date (End): October 12, 2009
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Ivani Credidio Trombetta
Grantee:Ivani Credidio Trombetta
Host: Virend Kristen Somers
Home Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Local de pesquisa : Mayo Clinic, Minnesota, United States  

Abstract

This study seeks to validate a new technique for evaluation of body composition through the scan with 3D image of the body volumes (BV), easy and safe application for the diagnosis of obesity. The aim of this study is first to assess the validity and diagnostic performance of BV to diagnose obesity when compared to various body composition techniques and obesity measures; and second, to asses the correlation between BV with several metabolic and clinical parameters to ultimately develop a risk model for cardiovascular outcomes and mortality.This new model of diagnosis may explain why conflicting results occur with the correlation of body mass index and mortality and cardiovascular events. We will recruit 300 patients (150 men/150 women), aged 18-70 years, referred to the cardiovascular health clinic to address the following aims: 1- To assess the validity and reproducibility of 3D BV; 2- To establish an obesity index based on 3D BV; 3- To assess if BV correlates better with metabolic parameters (total cholesterol, LDL, HDL, glucose, C-reactive protein, leptin, adiponectin, etc.) when compared to other body composition techniques and obesity measures; 4- To create a cardiovascular risk score using BV and other metabolic parameters (age, sex, lipid profile, glucose, inflammatory markers, endothelial function, etc.). (AU)

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TOSCHI-DIAS, EDGAR; TROMBETTA, IVANI C.; SILVA, VALDO J. D.; MAKI-NUNES, CRISTIANE; CEPEDA, FELIPE X.; ALVES, MARIA JANIEIRE N. N.; CARVALHO, GLAUCE L.; DRAGER, LUCIANO F.; LORENZI-FILHO, GERALDO; NEGRAO, CARLOS E.; RONDON, MARIA URBANA P. B. Diet associated with exercise improves baroreflex control of sympathetic nerve activity in metabolic syndrome and sleep apnea patients. Sleep and Breathing, v. 23, n. 1, p. 143-151, MAR 2019. Web of Science Citations: 2.
MAKI-NUNES, CRISTIANE; TOSCHI-DIAS, EDGAR; CEPEDA, FELIPE X.; RONDON, MARIA URBANA P. B.; ALVES, MARIA-JANIEIRE N. N.; FRAGA, RAFFAEL F.; BRAGA, ANA MARIA F. W.; AGUILAR, ADRIANA M.; AMARO, ALINE C.; DRAGER, LUCIANO F.; LORENZI-FILHO, GERALDO; NEGRAO, CARLOS E.; TROMBETTA, IVANI C. Diet and exercise improve chemoreflex sensitivity in patients with metabolic syndrome and obstructive sleep apnea. OBESITY, v. 23, n. 8, p. 1582-1590, AUG 2015. Web of Science Citations: 11.
TOSCHI-DIAS, EDGAR; TROMBETTA, IVANI C.; DIAS DA SILVA, VALDO J.; MAKI-NUNES, CRISTIANE; CEPEDA, FELIPE X.; ALVES, MARIA-JANIEIRE N. N.; DRAGER, LUCIANO F.; LORENZI-FILHO, GERALDO; NEGRAO, CARLOS E.; RONDON, MARIA URBANA P. B. Time delay of baroreflex control and oscillatory pattern of sympathetic activity in patients with metabolic syndrome and obstructive sleep apnea. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 304, n. 7, p. H1038-H1044, APR 2013. Web of Science Citations: 18.
TOSCHI-DIAS, EDGAR; TROMBETTA, IVANI C.; DIAS DA SILVA, VALDO JOSE; MAKI-NUNES, CRISTIANE; ALVES, MARIA JANIEIRE N. N.; ANGELO, LUCIANA F.; CEPEDA, FELIPE X.; MARTINEZ, DANIEL G.; NEGRAO, CARLOS EDUARDO; RONDON, MARIA URBANA P. B. Symptoms of anxiety and mood disturbance alter cardiac and peripheral autonomic control in patients with metabolic syndrome. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v. 113, n. 3, p. 671-679, MAR 2013. Web of Science Citations: 6.
MARTINEZ, DANIEL G.; NICOLAU, JOSE C.; LAGE, RONY L.; TOSCHI-DIAS, EDGAR; DE MATOS, LUCIANA D. N. J.; ALVES, MARIA JANIEIRE N. N.; TROMBETTA, IVANI C.; DIAS DA SILVA, VALDO J.; MIDDLEKAUFF, HOLLY R.; NEGRAO, CARLOS E.; RONDON, MARIA U. P. B. Effects of Long-Term Exercise Training on Autonomic Control in Myocardial Infarction Patients. Hypertension, v. 58, n. 6, p. 1049-U152, DEC 2011. Web of Science Citations: 60.
TROMBETTA, IVANI C.; SOMERS, VIREND K.; MAKI-NUNES, CRISTIANE; DRAGER, LUCIANO F.; TOSCHI-DIAS, EDGAR; ALVES, MARIA JANIEIRE N. N.; FRAGA, RAFFAEL F.; RONDON, MARIA URBANA P. B.; BECHARA, MALTA G.; LORENZI-FILHO, GERADO; NEGRAO, CARLOS E. Consequences of Comorbid Sleep Apnea in the Metabolic Syndrome-Implications for Cardiovascular Risk. Sleep, v. 33, n. 9, p. 1193-1199, SEP 1 2010. Web of Science Citations: 46.

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