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Effects of thyroid hormones on the regulation of the expression of proteins involved on lipolysis in subcutaneous and visceral white adipose tissue.

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Author(s):
Mariana de França Oliveira da Silva
Total Authors: 1
Document type: Master's Dissertation
Press: São Paulo.
Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
Defense date:
Examining board members:
Maria Tereza Nunes; Maria Luiza Morais Barreto de Chaves; Lila Missae Oyama
Advisor: Maria Tereza Nunes
Abstract

Thyroid hormones (TH) play an important lipolytic role in white adipose tissue (WAT). This effect is mediated by increased expression of beta-adrenergic receptors on adipocytes membrane, which increases the sensitivity of that tissue to catecholamines. It is known that the main effectors of the lipolytic action in WAT enzymatic activity, especially: hormone sensitive lipase (HSL) and adipose triglyceride lipase (ATGL), which hydrolyze triglycerides into fatty acids and glycerol. In addition, other components are involved in the lipolytic activity, such as perilipin. These proteins support the fat droplet, forming a protective barrier against HSL and ATGL action. Considering: (a) the importance of adipose tissue in energy homeostasis and as a source of cytokines which are related to insulin tissue sensitivity; (b) function and metabolism of adipose tissue vary with their regional distribution; and (c) lipolytic actions of HT, important regulators of energy homeostasis, have been little explored, we investigated in rats with hypothyroidism and submitted to T3 treatment: (i) TH effects on the expression of hormone sensitive lipase (HSL), adipose triglyceride lipase (ATGL),perilipin A and beta-3 adrenergic receptors in WAT, and (ii) if this action are different on subcutaneous and visceral fat depot. This study has increased our understanding about the contribution of these hormones on WAT metabolism and metabolic disease as obesity. (AU)

FAPESP's process: 13/09244-0 - Effect of thyroid hormone on the regulation of expression of proteins involved with lipolysis in subcutaneous and visceral white adipose tissue
Grantee:Mariana de França Oliveira da Silva
Support Opportunities: Scholarships in Brazil - Master