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Offspring from endurance-trained fathers inherits improved mitochondrial function through PPAR co-repressors decreased

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Ricardo Freitas-Dias
Total Authors: 1
Document type: Doctoral Thesis
Institution: Universidade Estadual de Campinas, Instituto de Biologia
Defense date:
Advisor: Everardo Magalhães Carneiro

Skeletal muscle capacity and mitochondrial function are tightly associated with glycemic control. The beneficial effects of exercise on glycemic control appear to be transmitted to offspring; however, the mechanisms underlying this transfer are still unknown. We investigated whether these benefits are related to the inheritance of skeletal muscle mitochondrial function and evaluated the possible signaling pathways involved. Male Swiss mice were subjected to 8 weeks of endurance training and mated with untrained females. The mitochondrial function and biogenesis of the offspring were assessed. As expected trained fathers demonstrated enhanced endurance performance, mitochondrial oxygen consumption, PGC-1? expression, and glycemic control. The offspring from trained mice also exhibited better endurance performance, mitochondrial oxygen consumption, glucose tolerance and insulin sensitivity. Intriguingly, PGC-1? expression and activity did not increase in the offspring from trained mice. However, lower levels of the PPAR co-repressors NCoR1 and RIP140 were detected. In conclusion, enhanced mitochondrial function is inherited by the offspring of trained fathers, and the signaling underlying this improved function is mediated by the decreased expression of PPAR co-repressors (AU)

FAPESP's process: 14/01717-9 - Investigation of the insulinotropic, insulinomimetic and endothelial actions of taurine in cells/tissues submitted to an in vitro amino acid restriction: an integrated and multifocal approach
Grantee:Everardo Magalhães Carneiro
Support type: Research Projects - Thematic Grants