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| Author(s): |
Natália Volgarine Scaraboto Bonfa
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | Ribeirão Preto. |
| Institution: | Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) |
| Defense date: | 2021-10-13 |
| Examining board members: |
Wilson Araújo da Silva Junior;
Pedro Alexandre Favoretto Galante;
Andréia Machado Leopoldino;
Vanessa da Silva Silveira
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| Advisor: | Wilson Araújo da Silva Junior |
| Abstract | |
HOX genes comprise a subgroup of the Homeobox family characterized by a high degree of conservation among fungi, plants, and animals. In mammals, there are 39 HOX genes distributed in four groups or clusters: HOXA, HOXB, HOXC, and HOXD, located on chromosomes 2, 7, 17, and 12, respectively. HOX genes are transcription factors that act during embryonic development, regulating fundamental biological processes such as proliferation, differentiation, migration, angiogenesis, and apoptosis. Several studies have also demonstrated an important role of HOX genes in tumorigenesis, involving a tissue-specific expression profile in different tumor types. Previous analyzes have shown that the HOXB2 gene is up-regulated in glioblastoma (GBM) and that its expression level is a significant factor in a patient\'s survival time. This work demonstrates that the HOXB2 gene regulates, in vitro, cell proliferation, senescence, and apoptosis in glioblastoma cell lines. NGS assays also elucidated potential targets of the HOXB2 gene and indicated its role in several critical biological pathways in the tumor context. Nevertheless, the genome organization in a glioblastoma cell line was demonstrated in the face of the HOXB2 interactions in promoters and enhancers. In summary, this is an original study that brings to light relevant information about the role of the HOXB2 gene in the regulation of Glioblastoma tumorigenesis. (AU) | |
| FAPESP's process: | 17/24027-6 - Analysis of gene pathways regulated by the HOXB2 gene in glioblastoma |
| Grantee: | Natália Volgarine Scaraboto Bonfa |
| Support Opportunities: | Scholarships in Brazil - Master |