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The effects of probiotic supplementation on the immune cells and on upper respiratory tract infection in endurance runners.

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Author(s):
Helena Angelica Pereira Batatinha
Total Authors: 1
Document type: Doctoral Thesis
Press: São Paulo.
Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
Defense date:
Examining board members:
José Cesar Rosa Neto; Ronaldo de Carvalho Araújo; Alison Colquhoun; Vinicius de Andrade Oliveira
Advisor: José Cesar Rosa Neto
Abstract

Probiotic supplementation arises as playing an immune-stimulatory role. High-intensity and -volume exercise can inhibit immune cell function, which threatens athletic performance and recovery. We hypothesized that 30 days of probiotic supplementation could stabilize the immune system of athletes preventing immune suppression after a marathon race. Twenty-seven male marathonists were double-blinded randomly into probiotic (Bifidobacterium-animalis-subsp.-Lactis (10x10 9) and Lactobacillus-Acidophilus (10x109) + 5 grams of maltodextrin) and placebo (5 grams of maltodextrin) group. They received 30 sachets and supplemented 1 portion/day during 30 days before the race. Blood was collected 30 days before (rest), 1 day before (pre), 1 hour after (post) and 5 days after the race (recovery). Both chronic and acute exercise modulated a different T lymphocyte population (CD3+CD4-CD8- T-cells), increasing pre-race, decreasing post, and returning to rest values at the recovery. The total number of CD8 T cell and the memory subsets statistically decreased only in the placebo group post-race. Pro-inflammatory cytokine production by stimulated lymphocytes decreased in the probiotic group after the supplementation period. 30 days of probiotic supplementation maintained CD8 T cell and effector memory cell population and played an immunomodulatory role in stimulated lymphocytes. Both, training, and marathon modulated a non-classical lymphocyte population regardless of probiotic supplementation. (AU)

FAPESP's process: 16/10561-8 - Probiotic Supplementation effect on oral microbiota modulation and upper respiratory tract infection in runners
Grantee:Helena Angélica Pereira Batatinha
Support Opportunities: Scholarships in Brazil - Doctorate