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PROCESS FOR MANUFACTURING AN INSOLUBLE BIOCATALYST

Document type:Patente
Inventor(s): Roberto de Campos Giordano; Raquel de Lima Camargo Giordano; Andrea Lopes de Oliveira Ferreira
Applicant: Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; Universidade Federal de São Carlos (UFSCAR)
Deposit date: November 2003, 24
INPI register:
DE2003634833 - INPI Search
IPC: C12M 1/40
Abstract

The purpose of the present invention is to provide a process for protection of enzymatic biocatalysts, constituted by a primary support, wrapped by a secondary matrix. More particularly, the invention is embodied as a bioreactor with a configuration that preserves the physical integrity and catalytic activity of the biocatalyst after long runs, and at the same time allows an easy separation of the protected biocatalyst from the solid, precipitated during the reaction course. Still more particularly, the invention refers to the use of the bioreactor herein described for the enzymatic synthesis of .beta.-lactam antibiotics, including the insoluble enzymatic catalysts, which have a primary matrix for immobilization involved by a secondary matrix, which is able to preserve 100% of the catalyst physical integrity and approximately 100% of its catalytic activity.


Grantee:Andrea Lopes de Oliveira Ferreira
Principal Investigator:Roberto de Campos Giordano
Institution: Universidade Federal de São Carlos (UFSCAR). Centro de Ciências Exatas e de Tecnologia (CCET)
Support type: Scholarships in Brazil - Doctorate

Grantee:Roberto de Campos Giordano
Principal Investigator:Roberto de Campos Giordano
Institution: Universidade Federal de São Carlos (UFSCAR). Centro de Ciências Exatas e de Tecnologia (CCET)
Support type: Research Grants - Support for Intellectual Property Rights and Licensing (PAPI/Nuplitec)