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USE OF CROTAMINE, KIT AND COMPOSITION 

Document type:Patente
Inventor(s): Tetsuo Yamane; Irina Kerkis; Alexandre Kerkis; Gandhi Rádis Baptista; Mirian Akemi Furuie Hayashi; Katsuhiro Konno; Álvaro Rossan de Brandão Prieto da Silva; Lygia da Veiga Pereira; Eduardo Brandt de Oliveira
Applicant: Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Deposit date: March 2006, 17
INPI register:
EP20060721611 - INPI Search
IPC: A61P 35/00 A61K 38/17 A61K 35/58 G01N 33/68 G01N 33/00 C07K 14/46
Abstract

The present invention refers to uses of crotamine and compositions containing it, based on its characteristic of interaction with genetic material. Under submicromolar quantities, the polypeptide is no longer toxic, presenting the characteristics properties of cell penetration, transport of molecules to the surface, cytoplasm or cell nucleus and particularly, selective cell penetration. The invention also refers to compositions comprising a pharmaceutically effective concentration of crotamine and its use for the treatment of diseases and dysfunctions, based on its characteristics of interaction with genetic material, such as DNA and RNA, and cell selectivity. Further, the invention refers to a kit comprising crotamine as a reagent to: (i) transfect or carry molecules to the surface, cytoplasm or nucleus of the cell or (ii) identify and select actively proliferating cells in a mixed cell population, particularly the ones originated from the umbilical cord and/or bone marrow.


Grantee:Tetsuo Yamane
Principal Investigator:Tetsuo Yamane
Institution: Secretaria da Saúde (São Paulo - Estado). Instituto Butantan
Support type: Regular Research Grants

Grantee:Mirian Akemi Furuie Hayashi
Principal Investigator:Mirian Akemi Furuie Hayashi
Institution: Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM)
Support type: Research Grants - Support for Intellectual Property Rights and Licensing (PAPI/Nuplitec)