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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Giovana da Silva Leandro in research grants and scholarships supported by FAPESP.
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Genomic instability due the accumulation of DNA lesions is extensively related to processes of aging and carcinogenesis. Therefore, mutations in genes involved in DNA repair lead to syndromes related to premature aging process and cancer susceptibility. In humans, mutations in genes related to nucleotide excision repair (NER) pathway are responsible for xeroderma pigmentosum (XP), with ex…
The genome of organisms is exposed to endogenous and exogenous agents, which can induce DNA damage and alter the integrity of DNA, generating genomic instability. Oxidative stress, one of the processes that can generate genomic instability in cells, is a condition resulting from lack of balance between the generation of free radicals and the effectiveness of antioxidant defense mechanisms…
R-loops are non B-DNA structures that are formed when a nascent RNA molecule anneals to a DNA template leaving a displaced single strand DNA. Those structures naturally occur in all organisms, but the lack of homeostasis leads to accumulation of those hybrids inducing genomic instability. There are several proteins involved in preventing the accumulation of those hybrids during the transc…
Oxidative stress seems to be strictly correlated with the development and progression of neurodegenerative diseases and also with the aging process itself. It has been reported that oxidative stress plays a role in the development of Alzheimer's disease (AD), which is a neurodegenerative disease with large impact on public health. Since base excision repair (BER) seems to be the main mech…
| 1 / 1 | Ongoing scholarships in Brazil |
| 3 / 3 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 6 / 6 | All Scholarships |
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