bachelor's at Farmácia Bioquímica from Universidade de Cruz Alta (2000), master's at Biochemistry from Universidade Federal de Santa Maria (2002) and doctorate at Bioquímica Toxicológica from Universidade Federal de Santa Maria (2006). Has experience in Biochemistry, focusing on Biochemistry, acting on the following subjects: organocalcogênios, toxicologia, disseleneto de difenila, convulsão and antinocicepção. (Source: Lattes Curriculum)
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During the JP-1 project we demonstrated that the oxidation of uric acid by neutrophil-peroxidases and production of urate hydroperoxide is an important event during the inflammatory oxidative burst. Urate hydroperoxide preferentially oxidized peroxiredoxins and the extracellular cell surface protein disulfide isomerase (PDI) and might affect redox signaling, inflammation, atherosclerosis …
The research group led by Prof. Meotti is interested to understand how the oxidants generated during the inflammatory oxidative burst modulate inflammatory cells and the surrounding cells response. The aim is to understand the role of the redox modulation in the maintenance, propagation and resolution of inflammation, mainly in chronic pathologies, describing the biochemical mechanisms of…
Cardiovascular disease (CD) due to atherosclerosis is the main cause of death in Brazil and developed countries. The atherogenesis is often associated with an impairment of the metabolism like hyperlipidemia and hyperuricemia. Overall, atherogenesis is accompanied of inflammatory process in the vase. In this situation, the level and the activity of myeloperoxidase, a pro-inflammatory enzy…
The inflammatory response consists of the mobilization of several cellular and molecular mechanisms in the face of infection or tissue injury to prevent damage to the organism. The cells involved in this process are accountable for synthesizing large concentrations of oxidant molecules, mainly for combating microorganisms and cellular signaling. It is essential to thoroughly understand th…
The production of reactive intermediates in the oxidation of uric acid is an important event during an inflammatory process. These intermediates can oxidize proteins and lipids. Preliminary data from our group appreciated that the oxidant power of uric acid induces an increase in triacylglycerols (TAGs) in neutrophils infected with Pseudomonas aeruginosa, modulating the lipid profile of t…
Sepsis, a severe infection associated with organ dysfunction, represents the main cause of death in Intensive Care Units (ICU) worldwide. The difficulty of effective treatment is due to the diverse pathogenesis of the disease, which varies depending on the individual characteristics of each patient's response. Therefore, understanding the metabolic and inflammatory status of each patient …
(Only some records are available in English at this moment)
Sepsis induces high mortality in patients admitted to intensive care units. It leads to high morbidity in recovered patients and has a relevant economic impact due to the length of stay and costs of treatment. The difficulty to find an effective treatment is a reflection of the diverse pathogenesis of the disease, which varies according to the individual response and characteristics of ea…
Peroxidasin (PXDN) is a heme-peroxidase expressed mainly at the extracellular matrix of the vascular endothelium. This enzyme catalyzes the oxidation of chloride or bromide by hydrogen peroxide producing the respective hypohalous acid. The products of PXDN oxidize collagen residues forming cross-linked chains at the basement membrane. In spite of this evidence, the physiological function …
Neutrophils have a major role in the innate immune system. These cells can produce a wide range of cytokines, and therefore are important regulators of inflammatory processes. The high oxidant production during oxidative burst suggest that these cells may have several signaling pathways under redox modulation, but studies focusing on intracellular redox signaling in neutrophils are scarce…
(Only some records are available in English at this moment)
Uric acid is the end product of purine metabolism in humans. Spite of being considered the main antioxidant in plasma, uric acid can be oxidized by inflammatory and extracellular matrix heme-peroxidases, generating urate free radical, which can trigger free radical chain reactions and lipid peroxidation. Interestingly, in the tumor milieu, both types of heme-peroxidases are abundantly exp…
Atherosclerosis is a chronic, lipid-induced disease of the arterial wall and is the leading cause of heart attacks and strokes, causing the majority of deaths and morbidity worldwide. The accumulation of oxidized low-density lipoproteins (OxLDL) and the infiltration of immune cells into the tissues trigger an inflammatory cellular response that leads to lesions and the formation of athero…
Peroxidasin (PXDN) is a heme peroxidase enzyme expressed in the extracellular matrix in several tissues. This enzyme catalyzes the formation of hypobromous acid (HOBr) from H2O2 and bromide. HOBr oxidizes amino acid residues to form covalent sulfilimine bonds in collagen IV in the basement membrane, a unique post-translational modification in biological systems. However, it is still uncle…
Reactive oxygen species (ROS) are well known for their role in mediating physiological cellular processes. In certain conditions, ROS levels may exceed the capacity of the cellular antioxidant system, which can cause damage to proteins. To alleviate the risk of irreversible protein aggregation, cells have developed a molecular chaperone system that binds unfolding proteins under stress co…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 3 / 2 | Completed research grants |
| 7 / 7 | Ongoing scholarships in Brazil |
| 12 / 10 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 6 / 6 | Completed scholarships abroad |
| 30 / 27 | All research grants and scholarships |
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CV Lattes
ORCID