Bachelor's at Veterinary Medicine at Universidade Estadual Paulista Júlio de Mesquita Filho (1993), master's in Science "Vétérinaires Option Reproduction" from Université de Montreal (1997) and doctorate at Genetics at the Universidade de São Paulo - Faculty of Medicine os Ribeirão Preto (1999). Has experience in Genetics, acting on the following subjects: mtdna, bos indicus, cattle, embryos, reprogramming and apoptosis. (Source: Lattes Curriculum)
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The present proposal establishes the continuity and expansion of the activities of the National Institute of Science and Technology in Stem Cells and Cell Therapy, one of the National Institutes of Science and Technology created by CNPq/FAPESP in 2008. In that opportunity, we proposed the development of an extensive program of basic and clinical research to understand, isolate, culture an…
We propose a program of basic and clinical research to isolate, culture, and characterize embryonic ,somatic, and neoplastic stem cells in order to understand their biology and apply this knowledge to therapy, comprising four research lines: (1) pluripotent stem cells (SC) (embryonic SC and induced pluripotent SC); (2) somatic SC (hematopoietic SC, mesenchymal SC, endothelial SC, and canc…
The proposal aims at the participation of the visiting researcher in a series of projects coordinated by the involved team. Including CEPID, INCT, Young Investigators and Regular Projects. Collaboration with Dr. Smith has been around for a long time, and in the recent years it has helped the team to be recognized in this area. His knowledge in his field of nuclear reprogramming has been r…
In humans and animals, control of ovulation, low oocyte fertility, occurrence of ovarian tumors, and development of polycystic ovaries or ovarian cysts are problems that need to be elucidated. The physiological and molecular knowledge of the mechanisms related to follicular growth, ovulation and oocyte competence are fundamental for the development of biotechnologies that contribute to th…
(Only some records are available in English at this moment)
Pigs have been used as an experimental model in biomedical research since Ancient Greece, mainly due to their physiological, anatomical, and genetic similarity with humans. Studies with transgenic porcine models are carried out to promote advances in scientific research, through the use of two tools, such as CrispR-Cas9 and in vitro production (IVP) of clone embryos through somatic cell n…
The bovine endometrium is constituted by stromal, glandular and luminal epithelial cells, with specific function and morphology. Epithelial cells are notable in luteolysis (PGF2±) and stromal cells in luteotrophic action (PGE2). Although the basic conditions of hormonal regulation in the endometrium are known, the molecular mechanisms are not fully elucidated. However, several studies in …
In ruminants, the definition of pregnancy begins with the migration of the blastocyst into the uterus. At this stage, the uterus support the initial development up to the embryo implantation. The uterine glands are involved in these processes, acting directly in the adaptation and regeneration of the endometrium. One of the fundamental functions of the uterine glands for embryonic develop…
In cattle, pregnancy failures occur more frequently during the period embryonic compared to the fetal or neonatal period. About,40% of all embryonic losses are associated with failures without maternal recognition prior to the 21st day of pregnancy. The acknowledgment maternal pregnancy is the period when the concept signals its presence for the mother. The production and release of EVs i…
(Only some records are available in English at this moment)
Early embryonic mortality is responsible for a large proportion of reproductive losses and usually occurs before maternal recognition of pregnancy (around day 16) in cattle. The IFNT secreted by the embryo signals its presence in the uterus to the mother, preventing luteolysis and embryonic loss. For the pregnancy to be maintained and the offspring to be healthy, proper communication betw…
Much has been discussed about embryonic loss in dairy and beef cattle, such losses are directly related to the failure in maternal embryonic communication in the uterus, and better understanding this communication is key to improve in vitro embryo production. Three-dimensional culture of endometrial cells, in which cells form a three-dimensional structure, improving intercellular communic…
A fully differentiated cell does not, naturally, return to cellular pluripotency. Although, somatic nuclear transfer, cloning, and other methodologies based on exogenous expression, shows cellular reversibility through nuclear reprogramming. Embryonic development and cell differentiation originate complex tissues and structures through differential gene expression. Furthermore, these proc…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 17 / 10 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 52 / 28 | Completed scholarships in Brazil |
| 10 / 10 | Completed scholarships abroad |
| 82 / 51 | All research grants and scholarships |
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CV Lattes
ORCID