CV Lattes
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Universidade de São Paulo (USP). Faculdade de Zootecnia e Engenharia de Alimentos (FZEA) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor's at Veterinary Medicine at Universidade Estadual Paulista Júlio de Mesquita Filho (1993), master's in Science ''Vétérinaires Option Reproduction'' from Université de Montreal (1997) and doctorate at Genetics at the Universidade de São Paulo - Faculty of Medicine os Ribeirão Preto (1999). Has experience in Genetics, acting on the following subjects: mtdna, bos indicus, cattle, embryos, reprogramming and apoptosis. (Source: Lattes Curriculum)
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O evento no workshop São Paulo que antecede a reunião anual da SBTE trará dois tópicos de interesse na área da biotecnologia da reprodução animal. Um sobre as perdas gestacionais que são relevantes para a biologia e para a pecuária e outro sobre os recém discutido caso de xenotransplante que terá participação de pesquisadores trabalhando diretamente no assunto da Alemanha e da dos EUA alé…
The proposal aims at the participation of the visiting researcher in a series of projects coordinated by the involved team. Including CEPID, INCT, Young Investigators and Regular Projects. Collaboration with Dr. Smith has been around for a long time, and in the recent years it has helped the team to be recognized in this area. His knowledge in his field of nuclear reprogramming has been r…
In humans and animals, control of ovulation, low oocyte fertility, occurrence of ovarian tumors, and development of polycystic ovaries or ovarian cysts are problems that need to be elucidated. The physiological and molecular knowledge of the mechanisms related to follicular growth, ovulation and oocyte competence are fundamental for the development of biotechnologies that contribute to th…
(Only some records are available in English at this moment)
Ovarian follicle development is characterized by several phases, beginning with the organization of primordial germ cells (PGCs), which differentiate into oogonia and interact with somatic cells to generate the primordial follicle. The transition from primordial to primary follicle is characterized by changes in the morphology of cumulus cells, which acquire a cuboidal shape. Subsequently…
Pigs have been used as an experimental model in biomedical research since Ancient Greece, mainly due to their physiological, anatomical, and genetic similarity with humans. Studies with transgenic porcine models are carried out to promote advances in scientific research, through the use of two tools, such as CrispR-Cas9 and in vitro production (IVP) of clone embryos through somatic cell n…
The bovine endometrium is constituted by stromal, glandular and luminal epithelial cells, with specific function and morphology. Epithelial cells are notable in luteolysis (PGF2±) and stromal cells in luteotrophic action (PGE2). Although the basic conditions of hormonal regulation in the endometrium are known, the molecular mechanisms are not fully elucidated. However, several studies in …
In ruminants, the definition of pregnancy begins with the migration of the blastocyst into the uterus. At this stage, the uterus support the initial development up to the embryo implantation. The uterine glands are involved in these processes, acting directly in the adaptation and regeneration of the endometrium. One of the fundamental functions of the uterine glands for embryonic develop…
(Only some records are available in English at this moment)
Biomedical models are essential to understanding human diseases and developing treatments. Rodents are generally favored due to their small size and low costs, but recently, swine species have increased interest due to their physiological and genetic similarities to humans. Genetically edited swine, utilizing CRISPR/Cas9 and somatic cell nuclear transfer (SCNT), have been established as v…
Early embryonic mortality is responsible for a large proportion of reproductive losses and usually occurs before maternal recognition of pregnancy (around day 16) in cattle. The IFNT secreted by the embryo signals its presence in the uterus to the mother, preventing luteolysis and embryonic loss. For the pregnancy to be maintained and the offspring to be healthy, proper communication betw…
Much has been discussed about embryonic loss in dairy and beef cattle, such losses are directly related to the failure in maternal embryonic communication in the uterus, and better understanding this communication is key to improve in vitro embryo production. Three-dimensional culture of endometrial cells, in which cells form a three-dimensional structure, improving intercellular communic…
A fully differentiated cell does not, naturally, return to cellular pluripotency. Although, somatic nuclear transfer, cloning, and other methodologies based on exogenous expression, shows cellular reversibility through nuclear reprogramming. Embryonic development and cell differentiation originate complex tissues and structures through differential gene expression. Furthermore, these proc…
(Only some records are available in English at this moment)