Bachelor's at Veterinary Medicine at Universidade Estadual Paulista Júlio de Mesquita Filho (1993), master's in Science "Vétérinaires Option Reproduction" from Université de Montreal (1997) and doctorate at Genetics at the Universidade de São Paulo - Faculty of Medicine os Ribeirão Preto (1999). Has experience in Genetics, acting on the following subjects: mtdna, bos indicus, cattle, embryos, reprogramming and apoptosis. (Source: Lattes Curriculum)
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We propose a program of basic and clinical research to isolate, culture, and characterize embryonic ,somatic, and neoplastic stem cells in order to understand their biology and apply this knowledge to therapy, comprising four research lines: (1) pluripotent stem cells (SC) (embryonic SC and induced pluripotent SC); (2) somatic SC (hematopoietic SC, mesenchymal SC, endothelial SC, and canc…
The proposal aims at the participation of the visiting researcher in a series of projects coordinated by the involved team. Including CEPID, INCT, Young Investigators and Regular Projects. Collaboration with Dr. Smith has been around for a long time, and in the recent years it has helped the team to be recognized in this area. His knowledge in his field of nuclear reprogramming has been r…
In humans and animals, control of ovulation, low oocyte fertility, occurrence of ovarian tumors, and development of polycystic ovaries or ovarian cysts are problems that need to be elucidated. The physiological and molecular knowledge of the mechanisms related to follicular growth, ovulation and oocyte competence are fundamental for the development of biotechnologies that contribute to th…
(Only some records are available in English at this moment)
The bovine endometrium is constituted by stromal, glandular and luminal epithelial cells, with specific function and morphology. Epithelial cells are notable in luteolysis (PGF2±) and stromal cells in luteotrophic action (PGE2). Although the basic conditions of hormonal regulation in the endometrium are known, the molecular mechanisms are not fully elucidated. However, several studies in …
In ruminants, the definition of pregnancy begins with the migration of the blastocyst into the uterus. At this stage, the uterus support the initial development up to the embryo implantation. The uterine glands are involved in these processes, acting directly in the adaptation and regeneration of the endometrium. One of the fundamental functions of the uterine glands for embryonic develop…
In cattle, pregnancy failures occur more frequently during the period embryonic compared to the fetal or neonatal period. About,40% of all embryonic losses are associated with failures without maternal recognition prior to the 21st day of pregnancy. The acknowledgment maternal pregnancy is the period when the concept signals its presence for the mother. The production and release of EVs i…
Oogenesis is the process of formation and differentiation of primordial female germinative cells until the generation of a fertilized egg. This is an event that begins in the prenatal life and ends in the adult life of the female. During the growth and development of the female the oocyte pool is found in Diplotene of Meiosis I, more precisely in the state known as germinal vesicle (GV). …
(Only some records are available in English at this moment)
Much has been discussed about embryonic loss in dairy and beef cattle, such losses are directly related to the failure in maternal embryonic communication in the uterus, and better understanding this communication is key to improve in vitro embryo production. Three-dimensional culture of endometrial cells, in which cells form a three-dimensional structure, improving intercellular communic…
A fully differentiated cell does not, naturally, return to cellular pluripotency. Although, somatic nuclear transfer, cloning, and other methodologies based on exogenous expression, shows cellular reversibility through nuclear reprogramming. Embryonic development and cell differentiation originate complex tissues and structures through differential gene expression. Furthermore, these proc…
Immediately after birth, mammalians possess an oocyte reserve estimated to be around 1 milion of cells.However, less than 1% of this pool will become a fertilizable oocyte. Part of this occurs due to a naturalprocess of selection during oogenesis. During the oocyte's growth phase, they must undergo a process ofcytoplasmic maturation, where they accumulate proteins, metabolites and RNAs es…
Induced pluripotent stem cells (iPSCs) obtained from different tissues allow us to generate relevant cell types that enable the formation or repair of damaged tissue and the generation of new in vitro models of syndromes or diseases. Moreover, human embryonic stem cells (hESCs) and iPSCs have recently been used to induced primordial germ cells like (PGCs-like), making then of great intere…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 16 / 9 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 51 / 27 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 8 / 8 | Completed scholarships abroad |
| 80 / 49 | All research grants and scholarships |
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CV Lattes
ORCID