CV Lattes
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Universidade de São Paulo (USP). Faculdade de Zootecnia e Engenharia de Alimentos (FZEA) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Bachelor's at Veterinary Medicine at Universidade Estadual Paulista Júlio de Mesquita Filho (1993), master's in Science "Vétérinaires Option Reproduction" from Université de Montreal (1997) and doctorate at Genetics at the Universidade de São Paulo - Faculty of Medicine os Ribeirão Preto (1999). Has experience in Genetics, acting on the following subjects: mtdna, bos indicus, cattle, embryos, reprogramming and apoptosis. (Source: Lattes Curriculum)
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In humans and animals, control of ovulation, low oocyte fertility, occurrence of ovarian tumors, and development of polycystic ovaries or ovarian cysts are problems that need to be elucidated. The physiological and molecular knowledge of the mechanisms related to follicular growth, ovulation and oocyte competence are fundamental for the development of biotechnologies that contribute to th…
The present proposal establishes the continuity and expansion of the activities of the National Institute of Science and Technology in Stem Cells and Cell Therapy, one of the National Institutes of Science and Technology created by CNPq/FAPESP in 2008. In that opportunity, we proposed the development of an extensive program of basic and clinical research to understand, isolate, culture an…
(Only some records are available in English at this moment)
The proposal aims at the participation of the visiting researcher in a series of projects coordinated by the involved team. Including CEPID, INCT, Young Investigators and Regular Projects. Collaboration with Dr. Smith has been around for a long time, and in the recent years it has helped the team to be recognized in this area. His knowledge in his field of nuclear reprogramming has been r…
Metabolomics is the field of science that looks at the spectrum of over 8,000 metabolites (metabolome) present in fluids (e.g. blood) and tissues (e.g. muscle), and which influence most biological processes in animals and plants. It is an emerging field in livestock that promises to revolutionize our understanding of relationships between the metabolic system, growth, and reproduction. On…
Genetically modified animals have numerous applications, ranging from basic research to livestock production and agriculture. Recent progress in animal cloning by nuclear transfer (NT) has made possible the production of transgenic animals using previously genetically modified cell lineages. However, to produce such lineages, an additional time for in vitro culturing and great manipulatio…
(Only some records are available in English at this moment)
In cattle, pregnancy failures occur more frequently during the period embryonic compared to the fetal or neonatal period. About,40% of all embryonic losses are associated with failures without maternal recognition prior to the 21st day of pregnancy. The acknowledgment maternal pregnancy is the period when the concept signals its presence for the mother. The production and release of EVs i…
In the past 20 years has been observed a decline in the fertility of dairy cows, whose etiology is complex. Several factors have been identified as the cause of reduced fertility, among them metabolic disorders such as negative energy balance (NEB). Cows in NEB increase serum concentrations of ketone bodies, and the ²-hydroxybutyric acid (BOHB) is the main ketone body circulating in cows.…
Oogenesis is the process of formation and differentiation of primordial female germinative cells until the generation of a fertilized egg. This is an event that begins in the prenatal life and ends in the adult life of the female. During the growth and development of the female the oocyte pool is found in Diplotene of Meiosis I, more precisely in the state known as germinal vesicle (GV). …
A fully differentiated cell does not, naturally, return to cellular pluripotency. Although, somatic nuclear transfer, cloning, and other methodologies based on exogenous expression, shows cellular reversibilitty through nuclear reprogramming. Embryonic development and cell differentiation originate complex tissues and structures from gene expression. Furthermore, these processes are regul…
The mammalian adult organism contains approximately two hundred different cell types. Each of these cells types possesses different functions and morphologies, which is controlled by the gene expression pattern. The chemical modifications present in the chromatin regulate gene expression and are called epigenetic modifications. The main functions of these modifications are to choose which…
(Only some records are available in English at this moment)
A fully differentiated cell does not, naturally, return to cellular pluripotency. Although, somatic nuclear transfer, cloning, and other methodologies based on exogenous expression, shows cellular reversibility through nuclear reprogramming. Embryonic development and cell differentiation originate complex tissues and structures through differential gene expression. Furthermore, these proc…
Immediately after birth, mammalians possess an oocyte reserve estimated to be around 1 milion of cells.However, less than 1% of this pool will become a fertilizable oocyte. Part of this occurs due to a naturalprocess of selection during oogenesis. During the oocyte's growth phase, they must undergo a process ofcytoplasmic maturation, where they accumulate proteins, metabolites and RNAs es…
Induced pluripotent stem cells (iPSCs) obtained from different tissues allow us to generate relevant cell types that enable the formation or repair of damaged tissue and the generation of new in vitro models of syndromes or diseases. Moreover, human embryonic stem cells (hESCs) and iPSCs have recently been used to induced primordial germ cells like (PGCs-like), making then of great intere…
In cattle, approximately 40% of all pregnancies are lost early during the first stages of pregnancies. The high rate of gestational loss is usually due to inefficient communication between the conceptus and mother. Thus, reducing embryonic losses through better understanding of embryonic signals can contribute significantly to the in vitro embryo production system by increasing efficienc…
The fertility of dairy cows has declined in the past half-century, and the metabolic disturbances (e.g. Negative Energy Balance (NEB)) incurred by high-yielding cows are believed to be the main reason for poor reproductive performance. NEB is characterized by elevated levels of nonesterified fatty acids (NEFAs) and ketone bodies (i.e., acetone, acetoacetate and ²-hydroxybutyrate) in the b…
(Only some records are available in English at this moment)
| 4 / 4 | Ongoing research grants |
| 14 / 7 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 48 / 24 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 6 / 6 | Completed scholarships abroad |
| 76 / 45 | All research grants and scholarships |
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