CV Lattes
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Ministério da Ciência, Tecnologia e Inovação (Brasil). Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Researcher at the National Laboratory of Biosciences (LNBio), part of the National Center for Research in Energy and Materials (CNPEM), since 2009. Holds a bachelor's degree (1999), master's degree (2002), and Ph.D. (2005) from UNICAMP. Completed postdoctoral training at the Butantan Institute (2006 to 2009) and the University of Virginia (2007/2009). Serves as the Americas representative on the Human Proteome Organization (HUPO) Council (2024 to 2026). Her research focuses on developing mass spectrometry-based proteomics methods, both discovery and targeted, applied to studying the biology of head and neck cancer at molecular, cellular, and systemic levels. Link to Research Line: https://lnbio.cnpem.br/divisoes-cientificas/nucleos-avancados-saude/proteomica/; link to Mass Spectrometry Laboratory: https://lnbio.cnpem.br/en/divisoes-cientificas/nucleos-avancados-saude/proteomica/ Link to http://scholar.google.com/citations?user=vey-6EgAAAAJhl=e (Source: Lattes Curriculum)
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Head and neck cancers (HNC) are considered the seventh most common cancer type worldwide. Squamous oral cell carcinomas are the most prevalent and are highly associated with lymph node metastasis, which leads to poor prognosis for patients. In a previous study, our group identified nodal metastasis signatures in the bulk lymphocytes and neutrophils. However, up to now, the heterogeneity b…
The study of single cells is essential to investigate the molecular mechanisms that support population heterogeneity and, consequently, the development of diseases, allowing accurate answers to the cell biology and biological processes associated with specific cell types. In this scenario, genomics and transcriptomics studies of single cells have revealed the composition of tissue microen…
Oral squamous cell carcinoma (OSCC) is the most common type of head and neck malignant tumor. Alcohol exposure is strongly associated with OSCC carcinogenesis, modifying the microenvironment. Our hypothesis is that alcohol exposure changes antigen processing and presentation through keratinocytes and fibroblast-derived extracellular vesicles (EV) that promote tolerance and suppress the im…
(Only some records are available in English at this moment)
Visite Plan: 1. Seminar at LNBio on the 'Role of ectodomain shedding of signaling proteins on extracellular vesicle for the tumor-supporting communication between cancer and supporter cells - options for targeted cancer therapy'. 2. Laboratory work: Introduction and help in establishing a test system to determine the metalloproteinase activity on the surface of extracellular vesicles. The…
(Only some records are available in English at this moment)
Agrin is a proteoglycan composed of multidomains, containing cleavage sites mainly in the N- and C-terminal portions, which leads to the formation of several potentially active fragments, the C-terminal of Agrin (C-22kDa) being the best studied in the context of cancer. Studies by our group such as Kawahara et al. (2014) and Rivera et al. (2018) have shown an association between agrin abu…
Proteomics allows us to analyze on a large scale the global content of proteins present indifferent biological systems through their identification and quantification, in addition to their post-translational modifications (PTMs). Literature studies, including those of our group, have demonstrated that omics-based analyzes on various biofluids allow understanding changes in these biomolecu…
Oral squamous cell carcinoma (OSCC) has a high incidence and mortality worldwide. The communication between tumor cells and the tumor microenvironment (TM) is essential for the cancer initiation and progression, and this communication can occur through extracellular vesicles (EVs). The TM is composed of several cell populations, including tumor-associated macrophages (TAMs) and dendritic …
(Only some records are available in English at this moment)
Head and neck cancer (HNC) is the seventh most common type of cancer, with a survival rate of approximately 50% after 5 years. The checkpoint inhibitors nivolumab and pembrolizumab are used as immunotherapies in the treatment of HNC; however, this procedure has a suboptimal durable response rate (~15%). These inhibitors target the PD-1 protein (programmed cell death 1 protein), which is h…
Treatment of patients with oral squamous cell carcinoma (OSCC) represents a clinical challenge. Despite advances in therapeutic modalities, OSCC recurrence rates vary between 18% to 76% in patients that received the standard treatment of surgery, radiotherapy and/or chemotherapy. Moreover, OSCC patients demonstrates a low response to other therapeutic modalities, such as EGFR monotherapy …
(Only some records are available in English at this moment)
Oral squamous cell carcinoma (OSCC) is a prevalent type of oral cancer, comprising 90% of all oral malignancies worldwide. The five-year survival rate of patients diagnosed at advanced stages of the disease (Stages III or IV) is approximately 20%, making clear that the discovery of diagnostic and prognostic markers is essential to improve OSCC patients' outcomes, as early detection and tr…
The diagnosis of oral squamous cell carcinoma (OSCC) is commonly realized in advanced stages, which leads to invasive therapies, decreased survival rates, and a worse prognosis. Even in São Paulo, the most developed state of Brazil, more than 70% of patients are diagnosed with stages III/IV disease. OSCC onset may be preceded by a group of oral disorders, such as oral leukoplakia (OL) and…
One of the major challenges of oral cancer is the late diagnosis, which affects the therapeutic treatment with a negative influence on prognosis and, consequently, survival rate. The standard treatments include surgery, radiotherapy, and/or chemotherapy. However, these treatments often result in numerous adverse side effects and multi-drug resistance, which leads to a poor therapeutic res…
Extracellular vesicles (EVs) are key players in cancer progression and metastasis by inducing changes in the tumour-microenvironment, extracellular matrix and pre-metastatic niches towards favourable sites for tumour growth and spread. Lymph node metastasis is the main prognostic factor in patients with oral squamous cell carcinoma (OSCC) and can decrease the 5-year survival rates to less…
(Only some records are available in English at this moment)
| 4 / 4 | Ongoing grants |
| 15 / 10 | Completed research grants |
| 11 / 11 | Ongoing scholarships in Brazil |
| 37 / 32 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 12 / 11 | Completed scholarships abroad |
| 80 / 69 | All research grants and scholarships |
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