Cristiane Figueiredo Pinho

• Abstract

  Prostate carcinogenesis has a hormonal basis, particularly through androgenic and estrogenic signaling. Evidence suggests that reduced expression of ER¿ and increased expression of ER¿ are associated with a microenvironment conducive to tumor progression. The modulation of these receptors thus emerges as a promising strategy in cancer therapy, constituting the primary mechanism of action …

  Hormonal modulation during prostate carcinogenesis in rats: role of Raloxifene, BP.IC

• Abstract

  The increasing use of plastic materials in society has raised significant concerns regarding the health impacts associated with their chemical components. Among them, phthalates, stand out for their potential effects as endocrine disruptors. Exposure to these plasticizers, particularly during critical developmental periods, may negatively influence the formation and homeostasis of various…

  Relationship between hormonal imbalances and proliferative lesions in the prostate of rats exposed to an environmentally relevant mixture of phthalates, BP.IC

• Abstract

  Phthalates are synthetic esters widely used as additives in the manufacturing of plastic products, being present in the composition of food packaging, clothes, paints, and personal care items. These compounds were classified as emerging environmental pollutants, which can cause several morphological, metabolic and reproductive alterations in exposed organisms, especially in hormone-depend…

  Perinatal exposure to phthalates and susceptibility to prostatic inflammation in adulthood, BP.IC

• Abstract

  Plasticizers are additives widely used in the manufacturing of plastic products, however, they represent a great risk to the environment and health of several organisms. Among these compounds are phthalates, environmental micropollutants that have mutagenic potential and can act as endocrine disruptors, capable of altering animal homeostasis, promoting several morphological, metabolic and…

  Endocrine disruption caused by perinatal exposure to phthalates: effects on the prostate of rats, BP.IC

• Abstract

  Prostate cancer's ability to progress to a non-responsive phase to androgen deprivation therapy emphasizes the importance of study on adjuvant treatments. Recent research suggests estrogen receptors as possible therapeutic targets in neoplasias and they can be modulated by drugs such as Raloxifene. In this context, this study aims to evaluate the histoprotective and anti-inflammatory pote…

  Effects of raloxifene therapy on MNU-induced prostatic inflammation in rats, BP.IC

• Abstract

  The prostate cancer presents hormonal basis for their initiation and progression of events and these are mainly related to changes involving estrogens and androgens inherent aging process, where there is an increase of androgens relative to estrogens. Nowadays, bisphenol A (BPA) is the most studied xenoestrogen and its estrogenic activity has attracted attention for its wide dispersion in…

  Chemoprotective potential of DIM (3,3 '-Di-indolyl-methane) and Genistein in LNCaP and PC-3 human prostate cancer cells exposed to Bisphenol A, BP.MS

(Only some records are available in English at this moment)