CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
He holds a degree in Pharmacy and Biochemistry from the University of São Paulo (1990), a master's degree in Biological Sciences (Biochemistry) from the University of São Paulo (1992) and a PhD in Analytical Chemistry - Marquette University, USA (1996). He did postdoctoral work at UW-Madison, School of Pharmacy, USA (1997) and was a visiting professor at Université Joseph Fourier in 2006 and at ENS-Lyon in 2024. He is currently a full professor and head of the Department of Biochemistry at the University of São Paulo and a member of the Academy of Sciences of the State of São Paulo. He serves as co-editor-in-chief of the journals "Journal of Photochemistry and Photobiology B: Biology" and "J. Photochem. Photobiol" (open) at Elsevier, pharmaceutical sciences editor of the journal "Recent Patents on Anti-Infective Drug Discovery" (Bentham Science), and is a member of the editorial board of Scientific Reports (Nature). He actively participates in the Brazilian Societies of Biochemistry and Molecular Biology (SBBQ), Chemistry (SBQ) and Biophysics (SBBf). He is a member of the Brazilian Academy of Sciences, the Academy of Sciences of the State of São Paulo, the board of the American Society of Photobiology (ASP) and vice-president of the International Union of Photobiology (2024-2029). His research interests include quantitative measurements in cells, membranes and interfaces, photochemistry, photobiology, photoprotection, photodynamic therapy, redox processes, regulated mechanisms of cell death. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Otro peligro del Sol |
| Further danger from the sun |
| More dangerous than the sun |
| Otro peligro del Sol |
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| News published in Agência FAPESP Newsletter about the researcher |
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The project presented here for this FAPERGS/FAPESP call is directly connected to the research lines that have been developed in the Bioinorganic and Porphyrinic Materials Laboratory (LBMP) at UFSM and in the Photoinduced Processes and Interfaces Laboratory (LPFI) at IQ-USP in recent years and which seeks to combine advances in porphyrin chemistry, especially new compounds with biomimetic …
Both groups (UK, whose PI is prof Pourzand and BR, whose PI is prof Baptista) study damage and protection of sun-exposed skin cells, aiming to develop better concepts and strategies for sun protection. The UK group is actively working in the role of iron and of photoaging and photoprotection in sun-exposed skin cells and the Brazilian group is doing similar efforts, but working mainly in …
Singlet oxygen (1O2) is the first excited state of molecular oxygen with 94.3 kJ/mol in excess of energy to its triplet ground state, and with a chemical reactivity completely different from that of molecular oxygen, as 1O2 can be added directly to double bonds. 1O2 plays important roles in materials science, and in the basic disciplines of physics, chemistry, biology and medicine, being …
(Only some records are available in English at this moment)
Singlet oxygen 1Deltag (1O2) is the first excited state of molecular oxygen with 94.3 kJ/mol in excess to its ground triplet state, and with a chemical reactivity completely different from that of molecular oxygen, as it can attack chemical bonds by two electron oxidations. 1O2 plays important roles in materials science, physics, chemistry, biology and medicine, being primarily responsibl…
Using the resources of the Technical Reserve for Institutional Infrastructure according to the rules specified by FAPESP. (AU)
(Only some records are available in English at this moment)
The present project aims to elucidate the influence of visible radiation, specifically blue and red wavelengths, on the processes of damage/inhibition and activation of skin cells. The literature describes that exposure to red light is related to cell activation. On the other hand, blue light is generally associated with harm. Visible light is capable of reaching both the dermis and epide…
The malignant transformation of keratynocites is not yet completely understood, and the effectsof blue light exposure have been completely ignored. We have previously demonstratedthat keratynocites accumulate lipofuscin and this process is somohow correlated with thefunction of lysosomes and the autophagic flux. We will use a combination of biophysicsand cellular physiology methods to elu…
(Only some records are available in English at this moment)
Sun exposure can cause several types of damage in the skin. Among the strategies for skin protection, blocking of sun radiation, UVA and UVB, stands out. However, UV radiation represents only 2% of the total irradiance of the sun, with the remaining 98% being visible and infrared radiation. The melanocytes, which are cells present in the stratum basale, are responsible for the production …
(Only some records are available in English at this moment)
The skin is continuously exposed to solar radiation and is our largest organ, offering an effective barrier against water loss and protection against external agents, among many other functions. Different light wavelengths have different effects on the skin. Most importantly for this project, they can differentially affect oxidative phosphorylation and metabolic fluxes in keratinocyte mit…
Sterols, referred to as the third lipid class, bear the essential triterpenoid scaffold, that ensure fluidity and flexibility to cell membranes, and serve as signaling important molecules crucial in growth, development and differentiation of organisms. The 7-Dehydrocholesterol (7-DHC) is a biosynthetic precursor of cholesterol and vitamin D3, and ergosterol. Similar to the polyunsaturated…
The project submitted here entitled "Ruthenium(II) complexes containing quinone based ligands to improve membrane damage and cause PDT response" is part of the postdoctoral project (2019/03195-3) and is related to a collaboration Project between Professor Mauricio da Silva Baptista (Universidade de São Paulo - Brazil) and Professor Claudia Turro (The Ohio State University). The strategy i…
Radical-mediated oxidations are expected to play an important role on photosensitized oxidations occuring in photodynamic therapy and cutaneous photoaging. Given the role of lipid photo-oxidation in these photobiological processes, in this project we aim to study the formation of lipid peroxyl radicals in model membranes, by using of BODIPY-a-tocopherol off/on fluorescent probes. These pr…
| 5 / 5 | Ongoing grants |
| 22 / 14 | Completed research grants |
| 8 / 8 | Ongoing scholarships in Brazil |
| 71 / 34 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 110 / 65 | All research grants and scholarships |
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