CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
He holds a degree in Pharmacy and Biochemistry from the University of São Paulo (1990), a Master's in Biological Sciences (Biochemistry) from the same university (1992), and a Ph.D. in Analytical Chemistry from Marquette University, USA (1996). He furthered his training with a post-doctorate at UW-Madison (1997) and visiting professorships at Université Joseph Fourier (2006) and ENS-Lyon (2024). At the University of São Paulo (USP), he rose to the position of Full Professor in the Biochemistry Department in 2012, serving as its Head from 2018 to 2022. His extensive academic management experience includes serving as Coordinator of Graduate Programs in Biochemistry (two terms) and the Professional Master's Program (one term), Chair of the Graduate Committee at the Institute of Chemistry (one term), and University Director of National and International Academic Cooperation. His scientific recognition is evidenced by his membership in the Brazilian Academy of Sciences and the São Paulo State Academy of Sciences, as well as in specialized national societies. On the global stage, he actively holds leadership positions as Vice-President of the International Union of Photobiology, President of the Latin American Branch of the American Society of Photobiology, and a board member of international scientific societies, in addition to being co-editor-in-chief of two Elsevier journals in the fields of photochemistry and photobiology. His research, focused on the fundamental mechanisms of light interaction with biological systems and innovation in photoprotection, has yielded hundreds of publications, dozens of international research projects, and several patentsincluding a new ingredient currently being tested by an international corporationalong with consulting work for the dermocosmetics industry. He is the recipient of numerous awards, including the Photocyte B Award (American Society of Photobiology, twice), the Humanitarian Award (International Union of Photobiology), and the Research Award (LatASP). He complements his work with a commitment to education in entrepreneurship, having developed and taught a specific module on the subject for undergraduate and graduate students. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Otro peligro del Sol |
| Further danger from the sun |
| More dangerous than the sun |
| Otro peligro del Sol |
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| News published in Agência FAPESP Newsletter about the researcher |
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Redox imbalance is a fundamental component of metabolic and chronic disorders, leading causes of death and morbidity worldwide. Although the involvement of redox processes in disease is widely recognized, the application of these findings to the resolution of pathologies is still limited, largely due to insufficient understanding of the specific molecular targets. In addition, the impact …
Sunlight is vital for life, yet its involvement in metabolic processes comes at a cost. When biomolecules absorb solar radiation, they become electronically excited, increasing their propensity for electron and energy transfer. This can lead to: (i) the production of reactive species that may be either beneficial or harmful, depending on their nature, quantity, and location, and (ii) evol…
The project presented here for this FAPERGS/FAPESP call is directly connected to the research lines that have been developed in the Bioinorganic and Porphyrinic Materials Laboratory (LBMP) at UFSM and in the Photoinduced Processes and Interfaces Laboratory (LPFI) at IQ-USP in recent years and which seeks to combine advances in porphyrin chemistry, especially new compounds with biomimetic …
(Only some records are available in English at this moment)
Singlet oxygen 1Deltag (1O2) is the first excited state of molecular oxygen with 94.3 kJ/mol in excess to its ground triplet state, and with a chemical reactivity completely different from that of molecular oxygen, as it can attack chemical bonds by two electron oxidations. 1O2 plays important roles in materials science, physics, chemistry, biology and medicine, being primarily responsibl…
Os temas em Foto-Ciências, que serão abordados no ELAFOT-LatASP, incluem pesquisas básicas e aplicadas com palestras plenárias convidadas, além de diversos simpósios (vide programa atachado). Entre os temas modernos e avançados destacamos: fotocatálise, técnicas de espectroscopia e microscopia com super-resolução temporal e espacial, fotofísica e fotoquímica de molécula única, nanopartícu…
Using the resources of the Technical Reserve for Institutional Infrastructure according to the rules specified by FAPESP. (AU)
(Only some records are available in English at this moment)
This project proposes the development of a new class of heteroleptically coordinated osmium(II) complexes of the type [Os(terpy)(bipy)(L)]², designed for application in Photodynamic Therapy (PDT). The central hypothesis is that the combination of near-infrared (NIR) absorption with a selective ligand photodissociation mechanism can provide an integrated solution to two fundamental challen…
The healing of diabetic wounds represents a significant clinical challenge, often associated with chronic infections, persistent inflammation, and a high risk of amputations, resulting in a major socioeconomic impact and a decrease in quality of life. The appearance of ulcers is frequently linked to the loss of sensation in distal limbs due to Diabetic Peripheral Neuropathy (DPN). Convent…
Solar radiation is composed of three main regions of the electromagnetic spectrum: ultraviolet (UV, 100-400nm), visible light (VL, 400-700nm), and infrared (>700nm). In the skin, UVA (320-400nm) and blue light (400-500nm) penetrate deeply into the epidermis and dermis, generating reactive species and free radicals that consequently promote oxidative damage to DNA and lipids. During autoph…
(Only some records are available in English at this moment)
The present project aims to elucidate the influence of visible radiation, specifically blue and red wavelengths, on the processes of damage/inhibition and activation of skin cells. The literature describes that exposure to red light is related to cell activation. On the other hand, blue light is generally associated with harm. Visible light is capable of reaching both the dermis and epide…
O projeto proposto tem a finalidade de capacitar o bolsista no gerenciamento e manipulação segura de produtos químicos bem como o desenvolvimento de atividades técnicas para o laboratório de Processos Fotoinduzidos e Interfaces, visando o aprendizado de técnicas relacionadas ao cultivo de células eucarióticas e células procarióticas.Nesse contexto, o projeto possibilitará ao bolsista apre…
Sunlight covers a wide range of electromagnetic waves in its spectrum, which includes the ultraviolet (UV-C, UV-B, UV-A), visible and infrared regions. UVA and UVB waves are well known for their effects on the skin, causing different damages, however, visible light, especially blue light, stands out due to its influence that is still poorly understood. Melanin, a product of synthesis in m…
(Only some records are available in English at this moment)
Light radiation, particularly visible light (VL) and blue light (BL), will be increasingly recognized as a source of oxidative stress in the skin, capable of penetrating deeply and inducing photoaging and pigmentation. Melanin, although protective against UV radiation, presents a photoprotective paradox: studies suggest that under VL exposure it may act as a photosensitizer, amplifying ce…
The skin is continuously exposed to solar radiation and is our largest organ, offering an effective barrier against water loss and protection against external agents, among many other functions. Different light wavelengths have different effects on the skin. Most importantly for this project, they can differentially affect oxidative phosphorylation and metabolic fluxes in keratinocyte mit…
Sterols, referred to as the third lipid class, bear the essential triterpenoid scaffold, that ensure fluidity and flexibility to cell membranes, and serve as signaling important molecules crucial in growth, development and differentiation of organisms. The 7-Dehydrocholesterol (7-DHC) is a biosynthetic precursor of cholesterol and vitamin D3, and ergosterol. Similar to the polyunsaturated…
The project submitted here entitled "Ruthenium(II) complexes containing quinone based ligands to improve membrane damage and cause PDT response" is part of the postdoctoral project (2019/03195-3) and is related to a collaboration Project between Professor Mauricio da Silva Baptista (Universidade de São Paulo - Brazil) and Professor Claudia Turro (The Ohio State University). The strategy i…
Radical-mediated oxidations are expected to play an important role on photosensitized oxidations occuring in photodynamic therapy and cutaneous photoaging. Given the role of lipid photo-oxidation in these photobiological processes, in this project we aim to study the formation of lipid peroxyl radicals in model membranes, by using of BODIPY-a-tocopherol off/on fluorescent probes. These pr…